ArticleInternational journal of clinical and experimental medicine2015
Dexmedetomidine attenuates isoflurane-induced cognitive impairment through antioxidant, anti-inflammatory and anti-apoptosis in aging rat.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The effect of intraoperative dexmedetomidine on cognitive dysfunction after surgery: a updated meta-analysis.Journal of cardiothoracic surgery · 2021Pooled it
- Protective Effects of Dexmedetomidine Infusion on Genotoxic Potential of Isoflurane in Patients Undergoing Emergency Surgery.International journal of clinical practice · 2023Trial
- Review
- From neurotoxicity to neuroprotection: Rethinking GABACell biology and toxicology · 2025Review
- Dexmedetomidine administration is associated with reduced mortality in patients with sepsis-induced acute respiratory distress syndrome: a retrospective study.BMC anesthesiology · 2025Article
- Dexmedetomidine upregulates microRNA-185 to suppress ovarian cancer growth via inhibiting the SOX9/Wnt/β-catenin signaling pathway.Cell cycle (Georgetown, Tex.) · 2021Article
- Sericin modulates learning and memory behaviors by tuning of antioxidant, inflammatory, and apoptotic markers in the hippocampus of aged mice.Molecular biology reports · 2021Article
- The Protective Effect and Mechanism of Dexmedetomidine on Diabetic Peripheral Neuropathy in Rats.Frontiers in pharmacology · 2020Article
- Hypothermia Following Spinal Anesthesia in an Infant: Potential Impact of Intravenous Dexmedetomidine and Intrathecal Clonidine.Journal of medical cases · 2019Article
- Dexmedetomidine Attenuates Lung Injury by Promoting Mitochondrial Fission and Oxygen Consumption.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Effect of dexmedetomidine anesthesia on respiratory function in pediatric patients undergoing retinoblastoma resection.Oncology letters · 2019Article
- Dexmedetomidine mitigates sevoflurane-induced cell cycle arrest in hippocampus.Journal of anesthesia · 2018Article
- Beneficial effects of dexmedetomidine on early postoperative cognitive dysfunction in pediatric patients with tonsillectomy.Experimental and therapeutic medicine · 2018Article
- Dexmedetomidine protects against glucocorticoid induced progenitor cell apoptosis in neonatal mouse cerebellum.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2017Article
- Dexmedetomidine Regulates 6-hydroxydopamine-Induced Microglial Polarization.Neurochemical research · 2017Article
- Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain.PloS one · 2017Article
- The Expression of VHL (Von Hippel-Lindau) After Traumatic Spinal Cord Injury and Its Role in Neuronal Apoptosis.Neurochemical research · 2016Article
- Effect of dexmedetomidine on hippocampal neuron development and BDNF-TrkB signal expression in neonatal rats.Neuropsychiatric disease and treatment · 2016Article
- Dose-related effects of dexmedetomidine on sepsis-initiated lung injury in rats.Brazilian journal of anesthesiology (Elsevier)Article
- The role of the locus coeruleus in the generation of pathological anxiety.Brain and neuroscience advancesReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a kind of α2 adrenergic receptor agonists, dexmedetomidine generates sedation, anti-anxiety and anesthesia effects by hyperpolarizing noradrenergic nerve cells in locus coeruleus. This study was designed to investigate the neuroprotective of dexmedetomidine attenuates isoflurane-induced cognitive impairment, and the possible underlying mechanism in aging rat. Firstly, we used isoflurane-induced aging rat model to analyze the therapeutical effect of dexmedetomidine on cognitive impairment. Next, commercial ELISA kits were used to analyze tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), methane dicarboxylic aldehyde (MDA) and superoxide dismutase (SOD) and caspase-3 levels. In addition, Western blotting was used to detect the protein expression of P38 MAPK, PTEN and phosphorylation-Akt (p-Akt) expression. Our results showed that the neuroprotective of dexmedetomidine significantly attenuates isoflurane-induced cognitive impairment in aging rat. Moreover, dexmedetomidine significantly inhibited these TNF-α, IL-1β, MDA, SOD and caspase-3 activities in isoflurane-induced aging rat. Meanwhile, the neuroprotective effects of dexmedetomidine on isoflurane-induced cognitive impairment significantly suppressed Bcl-xL/Bad rate, P38 MAPK and PTEN protein expression and activated p-Akt protein expression in aging rat. Collectively, neuroprotective effect of dexmedetomidine attenuates isoflurane-induced cognitive impairment through antioxidant, anti-inflammatory and anti-apoptosis in aging rat.
Indexed as
Identifiers
26770320PMC4694220W2409902128What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.