ReviewTherapeutic advances in gastroenterology2016
A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated Lactobacillus LB.
Review in Therapeutic advances in gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- A Systematic Review and Meta-Analysis:Nutrients · 2022Pooled it
- Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review.Nutrients · 2020Pooled it
- A Postbiotic ContainingMicroorganisms · 2026Article
- Postbiotics: An Overview and Recommendations for Improved Reporting.Molecular nutrition & food research · 2026Review
- Postbiotics derived from recombinant lactic acid bacteria exhibit high IL6-binding capacity and suppress IL6-induced STAT3 signaling.Frontiers in microbiology · 2025Article
- Benefits of heat-killedFrontiers in veterinary science · 2024Article
- Paraprobiotics: definition, manufacturing methods, and functionality.Food science and biotechnology · 2023Review
- Postbiotic effects of Lactobacillus fermentate on intestinal health, mucosa-associated microbiota, and growth efficiency of nursery pigs challenged with F18+Escherichia coli.Journal of animal science · 2022Article
- Gut health benefit and application of postbiotics in animal production.Journal of animal science and biotechnology · 2022Review
- A postbiotic consisting of heat-treated lactobacilli has a bifidogenic effect in pure culture and in human fermented faecal communities.Applied and environmental microbiology · 2021Article
- In Vitro Exploration of Probiotic Bacteria Interactions withPathogens (Basel, Switzerland) · 2021Article
- Postbiotics against Pathogens Commonly Involved in Pediatric Infectious Diseases.Microorganisms · 2020Review
- Review
- Pharmabiotic Manipulation of the Microbiota in Gastrointestinal Disorders: A Clinical Perspective.Journal of neurogastroenterology and motility · 2018Review
- Characterization of a Sea Buckthorn Extract and Its Effect on Free and Encapsulated Lactobacillus casei.International journal of molecular sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental in vitro and in vivo studies support the hypothesis that heat-treated, lyophilized Lactobacillus acidophilus LB cells and concentrated, neutralized spent culture medium conserve the variety of pharmacological, antimicrobial activities of the live probiotic strain against several infectious agents involved in well-established acute and persistent watery diarrhoea and gastritis. Heat-treated cells and heat-stable secreted molecules trigger multiple strain-specific activities explaining the therapeutic efficacy of L. acidophilus LB. This review discusses the current body of knowledge on the antimicrobial mechanisms of action exerted by L. acidophilus LB demonstrated in in vitro and in vivo experimental studies, and the evidence for the therapeutic efficacy of this anti-infectious biotherapeutic agent proved in randomized clinical trials for the treatment of acute and persistent watery diarrhoea associated with several intestinal infectious diseases in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.