ArticleAnnals of general psychiatry2016
Serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol levels in chronic schizophrenia.
Article in Annals of general psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Brain-derived neurotrophic factor (BDNF) changes in rodent models of schizophrenia induced by ketamine: a systematic review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Elucidating the Complex Etiology of Schizophrenia: Comprehensive Insights into the Therapeutic Roles of Natural Compounds and Pharmacological Interventions.Current pharmaceutical design · 2026Review
- A comparison of commercial assays quantifying mature brain-derived neurotrophic factor (mBDNF) and its precursor (pro-BDNF) in human serum.Scientific reports · 2025Article
- Suicidal ideation with and without intention to act: A transdiagnostic network analysis on the interplay between psychopathology, impulsivity, and childhood maltreatment.Psychological medicine · 2025Article
- Serum BDNF Increase After 9-Month Contemplative Mental Training Is Associated With Decreased Cortisol Secretion and Increased Dentate Gyrus Volume: Evidence From a Randomized Clinical Trial.Biological psychiatry global open science · 2025Article
- Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combiningiScience · 2022Article
- Association between hippocampal structure and serum Brain-Derived Neurotrophic Factor (BDNF) in healthy adults: A registered report.NeuroImage · 2021Article
- Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders.Scientific reports · 2017Article
- Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection.Neural plasticity · 2017Review
- Negative symptoms in schizophrenia.Industrial psychiatry journalReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated the serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in patients with chronic schizophrenia.
methodsSixty-eight patients who met the DSM-IV-TR criteria and had a chronic schizophrenia (CS) duration of ≥ 5 years were enrolled. Their serum brain-derived BDNF and proBDNF levels were measured by enzyme-linked immunosorbent assays, and their plasma MHPG levels were analyzed by high-performance liquid chromatography with electrochemical detection.
resultsThe plasma MHPG levels were significantly lower in the CS group (3.9 ± 1.8 ng/ml) compared to those in the group of 32 age- and sex-matched healthy controls (5.1 ± 2.4 ng/ml). The serum BDNF levels were significantly lower in the CS group (8.9 ± 4.8 ng/ml) compared to the control group (12.2.1 ± 6.8 ng/ml). No correlation was observed between plasma MHPG and BDNF in the CS group.
conclusionThese results suggest that hypo-activity of noradrenergic neurons and decreased BDNF secretion exist in chronic schizophrenic patients.
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