Evidence map›Paper›PMID 26770255›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2015

In Vitro Antimicrobial Activity and Effect on Biofilm Production of a White Grape Juice (Vitis vinifera) Extract.

Angela Filocamo, Carlo Bisignano, Giuseppina Mandalari, Michele Navarra

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Plant Extracts as Modulators of the Wound Healing Process-Preliminary Study.International journal of molecular sciences · 2025
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  3. GABAPharmaceuticals (Basel, Switzerland) · 2025
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  4. Chemical Profile and Antibacterial Activity ofFoods (Basel, Switzerland) · 2024
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  5. Antibiotics (Basel, Switzerland) · 2024
    Review
  6. Antimicrobial Activity of Crude Metabolites ofJournal of pharmacy & bioallied sciences · 2024
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  7. Frontiers in microbiology · 2024
    Review
  8. Pharmaceutics · 2023
    Review
  9. Article
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  15. Article
  16. The Digestibility ofNutrients · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Angela FilocamoDepartment of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Viale Annunziata, 98168 Messina, Italy.
Carlo BisignanoDepartment of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Viale Annunziata, 98168 Messina, Italy.
Giuseppina MandalariDepartment of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Viale Annunziata, 98168 Messina, Italy.
Michele NavarraDepartment of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Viale Annunziata, 98168 Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. The aim of the present study was to evaluate the antimicrobial effect of a white grape juice extract (WGJe) against a range of Gram-positive and Gram-negative bacteria, yeasts, and the fungus Aspergillus niger. WGJe was also tested on the production of bacterial biofilms in vitro. Results. WGJe inhibited in vitro most Gram-positive bacteria tested, Staphylococcus aureus ATCC 6538P being the most sensitive strain (MIC values of 3.9 μg/mL). The effect was bactericidal at the concentration of 500 μg/mL. Amongst the Gram-negative bacteria, Escherichia coli was the only susceptible strain (MIC and MBC of 2000 μg/mL). No effect on the growth of Candida sp. and the fungus Aspergillus niger was detected (MIC values > 2000 μg/mL). WGJe inhibited the biofilms formation of E. coli and Pseudomonas aeruginosa with a dose-dependent effect. Conclusions. WGJe exerted both bacteriostatic and bactericidal activity in vitro. The presented results could be used to develop novel strategies for the treatment of skin infections and against potential respiratory pathogens.

Identifiers

PMID26770255
PMCPMC4685099
OpenAlexW2195853864

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.