ReviewStem cells international2016
Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform?
Review in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of the adipose stem cells in burn wound healing: literature review.Cell and tissue banking · 2022Pooled it
- Hypoxia-preconditioned gingiva-derived mesenchymal stem cell-conditioned medium accelerates burn wound healing.Scientific reports · 2026Article
- Real-World Use of a Decellularized Porcine Placental Extracellular Matrix in Hard-to-Heal Wounds: A Retrospective, Single-Center Study.Journal of clinical medicine · 2025Article
- African Medicinal Plants in Cutaneous Wound Repair: A Comprehensive Analysis of the Role of Phytochemicals.International wound journal · 2025Review
- Recent advances in the role of neuroregulation in skin wound healing.Burns & trauma · 2025Review
- Revolutionizing dermatology: harnessing mesenchymal stem/stromal cells and exosomes in 3D platform for skin regeneration.Archives of dermatological research · 2024Review
- The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Increases Fibroblast Growth Factor 2 and Insulin-Like Growth Factor 1 in Full-Thickness Burns in Animal Model.Annals of burns and fire disasters · 2024Article
- Vascular endothelial growth factor a modified mRNA engineered cellular electrospun membrane complexes promotes mouse skin wound repair.Materials today. Bio · 2023Article
- Plasticity of Epithelial Cells during Skin Wound Healing.Cold Spring Harbor perspectives in biology · 2023Review
- Anti-inflammatory effect of interleukin-6 highly enriched in secretome of two clinically relevant sources of mesenchymal stromal cells.Frontiers in cell and developmental biology · 2023Article
- Bioengineered MSC-derived exosomes in skin wound repair and regeneration.Frontiers in cell and developmental biology · 2023Review
- Research update of adipose tissue-based therapies in regenerative dermatology.Stem cell reviews and reports · 2022Review
- Focus on the Contribution of Oxidative Stress in Skin Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review).Biomedicines · 2022Review
- Decellularized Tissues for Wound Healing: Towards Closing the Gap Between Scaffold Design and Effective Extracellular Matrix Remodeling.Frontiers in bioengineering and biotechnology · 2022Review
- Bacterial Cellulose as a Potential Bio-Scaffold for Effective Re-Epithelialization Therapy.Pharmaceutics · 2021Article
- Mesenchymal Stem Cell-derived Extracellular Vesicles for Skin Wound Healing.Advances in experimental medicine and biology · 2021Article
- In Vitro Wound Healing Potential of Photobiomodulation Is Possibly Mediated by Its Stimulatory Effect on AKT Expression in Adipose-Derived Stem Cells.Oxidative medicine and cellular longevity · 2021Article
- Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation ofPharmaceuticals (Basel, Switzerland) · 2020Article
- Celery (Veterinary world · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound reepithelialization is a cooperative multifactorial process dominated by keratinocyte migration, proliferation, and differentiation that restores the intact epidermal barrier to prevent infection and excessive moisture loss. However, in wounds that exhibit impaired wound healing, such as chronic nonhealing wounds or hypertrophic scars, the reepithelialization process has failed. Thus, it is necessary to explore a suitable way to mitigate these abnormalities to promote reepithelialization and achieve wound healing. Mesenchymal stem cells (MSCs) have the capacity for self-renewal as well as potential multipotency. These cells play important roles in many biological processes, including anti-inflammation, cell migration, proliferation, and differentiation, and signal pathway activation or inhibition. The mechanism of the involvement of MSCs in reepithelialization is still not fully understood. An abundance of evidence has shown that MSCs participate in reepithelialization by inhibiting excessive inflammatory responses, secreting important factors, differentiating into multiple skin cell types, and recruiting other host cells. This review describes the evidence for the roles that MSCs appear to play in the reepithelialization process.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.