Evidence map›Paper›PMID 26770089›Full record

ArticleIntegrative medicine (Encinitas, Calif.)2014

A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease.

Jeannette Painovich, Anita Phancao, Puja Mehta, Supurna Chowdhury, Shivani Dhawan, Ning Li, Doris Taylor, Yi Qiao, Anna Brantman, Xiuling Ma and 1 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Integrative medicine (Encinitas, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jeannette Painovichis a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Anita Phancaois a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Puja Mehtais a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Supurna Chowdhuryis a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Shivani Dhawanis a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Ning Liis a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Doris Tayloris a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Yi Qiaois a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Anna Brantmanis a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Xiuling Mais a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
C Noel Bairey Merzis a research acupuncturist; is a cardiology fellow; is director of the Non-Invasive Vascular Function Research Lab; is a research associate III; is a clinical research associate II; is a research scientist and assistant professor; is an acupuncturist; is an acupuncturist; is an acupuncturist; and is a professor of medicine and the center director. All are located at Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute of the Cedars-Sinai Medical Center in Los Angeles, California. is the director of regenerative medicine research at the Texas Heart Institute in Houston, Texas.
Institut für Sozialforschung und Sozialwirtschaft · DE

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
Effects of Traditional Acupuncture on Mechanisms of CHDR01AT001482 · NCCIH · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2005 to 2009
$2.1M
NCCIH NIH HHS R01 AT001482NCRR NIH HHS M01 RR000425
6 · The paper itself

Abstract

contextCoronary heart disease (CHD) remains the number one killer of men and women in the United States, and despite traditional secondary prevention, individuals with the disease remain at risk. Endothelial progenitor cells (EPCs) may have beneficial effects on atherosclerosis, angiogenesis, and vascular repair and may contribute systemically to ongoing endogenous repair processes. Traditional acupuncture (TA), a modality used in the practice of Chinese medicine, appears to have beneficial effects in many areas associated with CHD.

objectiveThe study examined the effects of TA on circulating EPCs in individuals with CHD.

designThe research team performed a randomized, controlled pilot study.

settingAll interventions were performed at the Cedars-Sinai Medical Center in Los Angeles, CA.

participantsThe study included 13 participants in 3 groups: (1) TA (n = 5), (2) sham acupuncture (SA, n = 5), or (3) waiting control (WC, n = 3).

interventionThe TA group received acupuncture treatments for 12 wk at CHD-specific sites, while the SA group received no-needle pressure at nonacupuncture sites for the same period, and the WC group received no intervention. OUTCOME MEASURES: The study measured the number of EPCs circulating in peripheral blood to determine cell surface markers for expressions of cluster of differentiation 34, 133 (CD34+/CD133+) and vascular endothelial growth factor receptor 2 (VEGF-R2+).

resultsEight men and 5 women with a mean age of 59 ± 10.9 y were included. Compared with their measurements at baseline, members of the TA group had a significantly greater change in the level of EPCs expressing CD34+/VEGF-R2+ compared with the SA group (P = .04). No group differences were evident in immature EPCs expressing CD34+/CD133+.

conclusionThe study's results suggest that TA can alter the number of EPCs circulating in peripheral blood by increasing the mobilization of the VEGF-R2+ EPC subpopulations. Further studies are warranted to evaluate whether TA can beneficially affect CHD via augmentation of EPC regenerative pathways.

Identifiers

PMID26770089
PMCPMC4684127
OpenAlexW2413757152

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.