Evidence map›Paper›PMID 26770036›Full record

ArticleJournal of Korean medical science2016

Total Lesion Glycolysis Using ¹⁸F-FDG PET/CT as a Prognostic Factor for Locally Advanced Esophageal Cancer.

Ji Hyung Hong, Hyon Ho Kim, Eun Ji Han, Jae Ho Byun, Hong Seok Jang, Eun Kyoung Choi, Jin Hyoung Kang, Ie Ryung Yoo

Abstract read
In one paragraph

Article in Journal of Korean medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The prognostic value of pretreatment [European radiology · 2025
    Pooled it
  2. Standardized Uptake Values Derived fromContrast media & molecular imaging · 2018
    Pooled it
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  4. Association of dynamic contrast-enhanced MRI andEuropean journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2023
    Article
  5. Article
  6. IntegratingThoracic cancer · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Predictive value ofF1000Research · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. International journal of clinical and experimental pathology · 2019
    Article
  16. Observational
  17. Article
  18. Radiologia brasileira
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ji Hyung HongDepartment of Internal Medicine, Incheon St. Mary's Hospital, Incheon, Korea.ORCID 0000-0002-0492-3959
Hyon Ho KimDepartment of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea.
Eun Ji HanDepartment of Nuclear Medicine, Daejeon St. Mary's Hospital, Daejeon, Korea.
Jae Ho ByunDepartment of Internal Medicine, Incheon St. Mary's Hospital, Incheon, Korea.
Hong Seok JangDepartment of Radiation Oncology, Seoul St. Mary's Hospital, Seoul, Korea.
Eun Kyoung ChoiDepartment of Nuclear Medicine, Incheon St. Mary's Hospital, Incheon, Korea.
Jin Hyoung KangDepartment of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea.
Ie Ryung YooDepartment of Nuclear Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) have been considered prognostic factors for survival in many cancers. However, their prognostic value for radiotherapy-treated squamous esophageal cancer has not been evaluated. In this study, SUV, MTV, and TLG were measured to predict their prognostic role in overall survival (OS) in 38 esophageal cancer patients who had undergone (18)F-FDG PET/CT before radiotherapy. TLG demonstrated higher sensitivity and specificity for predicting OS than MTV and SUV; and a better OS was observed in patients with low TLG compared to those with high TLG in locally advanced disease (OS, 46.9 months; 95% confidence interval [CI], 33.50-60.26 vs. 25.3 months; 95% CI, 8.37-42.28; P=0.003). Multivariate analyses in these patients determined that TLG and the use of combination chemotherapy were the independent prognostic factors for OS (hazard ratio [HR], 7.12; 95% CI, 2.038-24.857; P=0.002 and HR, 6.76; 95% CI, 2.149-21.248; P=0.001, respectively). These results suggest that TLG is an independent prognostic factor for OS and a better predictor of survival than MTV and SUV in patients with locally advanced esophageal cancer treated with radiotherapy.

Indexed as

Positron-Emission TomographyTomography, X-Ray ComputedAdultAgedAged, 80 and overArea Under CurveEsophageal NeoplasmsFemaleFluorodeoxyglucose F18GlycolysisHumansMaleMiddle AgedNeoplasm StagingPrognosisProportional Hazards ModelsFluorodeoxyglucose F18RadiopharmaceuticalsEsophageal Neoplasms, 18F-FDG PET/CTMetabolic Tumor VolumeTotal Lesion Glycolysis

Identifiers

PMID26770036
PMCPMC4712578

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.