ArticleBioinformation2015
Shape based virtual screening and molecular docking towards designing novel pancreatic lipase inhibitors.
Article in Bioinformation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Structure-Based Discovery of Orthosteric Non-Peptide GLP-1R Agonists via Integrated Virtual Screening and Molecular Dynamics.International journal of molecular sciences · 2025Article
- Exploring flavonoid derivatives as potential pancreatic lipase inhibitors for obesity management: An in silico and in vitro study.Molecular diversity · 2025Article
- Exploring the anti-obesity bioactive compounds ofRSC advances · 2023Article
- Potential Effect of Baobab's Polyphenols as Antihyperlipidemic Agents: In Silico Study.Molecules (Basel, Switzerland) · 2023Article
- Papaverinol-Molecules (Basel, Switzerland) · 2023Article
- Inhibition of α-Glucosidase and Pancreatic Lipase Properties ofNutrients · 2022Article
- A molecular modelling approach for identifying antiviral selenium-containing heterocyclic compounds that inhibit the main protease of SARS-CoV-2: an in silico investigation.Briefings in bioinformatics · 2021Article
- Identification of Key Pathways and Genes in Obesity Using Bioinformatics Analysis and Molecular Docking Studies.Frontiers in endocrinology · 2021Article
- Cocoa (Foods (Basel, Switzerland) · 2020Article
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- Pharmacophore Directed Screening of Agonistic Natural Molecules Showing Affinity to 5HTBiomolecules · 2019Article
- A marine sponge associated fungal metabolite monacolin X suppresses angiogenesis by down regulating VEGFR2 signaling.RSC advances · 2019Article
- Combined e-pharmacophore based screening and docking of PI3 kinase with potential inhibitors from a database of natural compounds.Bioinformation · 2019Article
- Structure⁻Activity Relationship and Molecular Docking of Natural Product Library Reveal Chrysin as a Novel Dipeptidyl Peptidase-4 (DPP-4) Inhibitor: An Integrated In Silico and In Vitro Study.Molecules (Basel, Switzerland) · 2018Article
- Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract ofFrontiers in pharmacology · 2018Article
- Methyl Chavicol and Its Synthetic Analogue as Possible Antioxidant and Antilipase Agents Based on theOxidative medicine and cellular longevity · 2018Article
- SMMDB: a web-accessible database for small molecule modulators and their targets involved in neurological diseases.Database : the journal of biological databases and curation · 2018Article
- Study of Antiobesity Effect through Inhibition of Pancreatic Lipase Activity of Diospyros kaki Fruit and Citrus unshiu Peel.BioMed research international · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increase in obesity rates and obesity associated health issues became one of the greatest health concerns in the present world population. With alarming increase in obese percentage there is a need to design new drugs related to the obesity targets. Among the various targets linked to obesity, pancreatic lipase was one of the promising targets for obesity treatment. Using the in silico methods like structure based virtual screening, QikProp, docking studies and binding energy calculations three molecules namely zinc85531017, zinc95919096 and zinc33963788 from the natural database were reported as the potential inhibitors for the pancreatic lipase. Among them zinc95919096 presented all the interactions matching to both standard and crystal ligand and hence it can be further proceeded to drug discovery process.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.