ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Interaction between environmental temperature and hypoxia on central and peripheral fatigue during high-intensity dynamic knee extension.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Performance changes during and post-exercise in combined heat and hypoxia environments: a systematic review and network meta analysis.Journal of translational medicine · 2026Pooled it
- A mathematical model for predicting cardiovascular responses at rest and during exercise in demanding environmental conditions.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Pooled it
- The 2026 Men's FIFA Football World Cup: Evidence-Based Guidelines to Protect Player Health and Performance from Environmental Challenges.Sports medicine (Auckland, N.Z.) · 2026Review
- Combined effects of normobaric hypoxia and cold on respiratory system responses to high-intensity exercise.Experimental physiology · 2025Article
- Profiling measures of muscle strength and power throughout a 156 km ultra-trail running event.Frontiers in sports and active living · 2025Article
- Independent, additive and interactive effects of acute normobaric hypoxia and cold on submaximal and maximal endurance exercise.European journal of applied physiology · 2024Article
- Effects of high-intensity interval training in a cold environment on arterial stiffness and cerebral hemodynamics in sedentary Chinese college female students post-COVID-19.Frontiers in neurology · 2024Article
- Impact of high intensity interval exercise with and without heat stress on cardiovascular and aerobic performance: a pilot study.BMC sports science, medicine & rehabilitation · 2023Article
- Combining hypoxia with thermal stimuli in humans: physiological responses and potential sex differences.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Review
- Practicing Sport in Cold Environments: Practical Recommendations to Improve Sport Performance and Reduce Negative Health Outcomes.International journal of environmental research and public health · 2021Review
- An examination of five theoretical foundations associated with localized thermosensory testing.European journal of applied physiology · 2021Article
- Neuromuscular Adaptations after an Altitude Training Camp in Elite Judo Athletes.International journal of environmental research and public health · 2021Article
- Exercise-Induced Hypoxemia in Endurance Athletes: Consequences for Altitude Exposure.Frontiers in sports and active living · 2021Review
- Self-Selected Motivational Music Enhances Physical Performance in Normoxia and Hypoxia in Young Healthy Males.Frontiers in psychology · 2021Article
- Contemporary Periodization of Altitude Training for Elite Endurance Athletes: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2019Review
- Anchoring biases affect repeated scores of thermal, moisture, tactile and comfort sensations in transient conditions.International journal of biometeorology · 2018Article
- Computational and Complex Network Modeling for Analysis of Sprinter Athletes' Performance in Track Field Tests.Frontiers in physiology · 2018Article
- Effects of Recreational Ski Mountaineering on Cumulative Muscle Fatigue - A Longitudinal Trial.Frontiers in physiology · 2018Article
- Hypoxia and Fatigue Impair Rapid Torque Development of Knee Extensors in Elite Alpine Skiers.Frontiers in physiology · 2018Article
- Separate and combined effects of exposure to heat stress and mental fatigue on endurance exercise capacity in the heat.European journal of applied physiology · 2017Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated causative factors behind the expression of different interaction types during exposure to multistressor environments. Neuromuscular fatigue rates and time to exhaustion (TTE) were investigated in active men (n = 9) exposed to three climates [5 °C, 50% relative humidity (rh); 23 °C, 50% rh; and 42 °C, 70% rh] at two inspired oxygen fractions (0.209 and 0.125 FiO2; equivalent attitude = 4,100 m). After a 40-min rest in the three climatic conditions, participants performed constant-workload (high intensity) knee extension exercise until exhaustion, with brief assessments of neuromuscular function every 110 s. Independent exposure to cold, heat, and hypoxia significantly (P < 0.01) reduced TTE from thermoneutral normoxia (reductions of 190, 405, and 505 s from 915 s, respectively). The TTE decrease was consistent with a faster rate of peripheral fatigue development (P < 0.01) compared with thermoneutral normoxia (increase of 1.6, 3.1, and 4.9%/min from 4.1%/min, respectively). Combined exposure to hypoxic-cold resulted in an even greater TTE reduction (-589 s), likely due to an increase in the rate of peripheral fatigue development (increased by 7.6%/min), but this was without significant interaction between stressors (P > 0.198). In contrast, combined exposure to hypoxic heat reduced TTE by 609 s, showing a significant antagonistic interaction (P = 0.003) similarly supported by an increased rate of peripheral fatigue development (which increased by 8.3%/min). A small decline (<0.4%/min) in voluntary muscle activation was observed only in thermoneutral normoxia. In conclusion, interaction type is influenced by the impact magnitude of the effect of the individual stressors' effect on exercise capacity, whereby the greater the effect of stressors, the greater the probability that one stressor will be abolished by the other. This indicates that humans respond to severe and simultaneous physiological strains on the basis of a worst-strain-takes-precedence principle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.