ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Role of CO2 in the cerebral hyperemic response to incremental normoxic and hyperoxic exercise.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Intracranial vasomotor and blood flow responses to light-intensity aerobic exercise in young adults: a 4D flow MRI study.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Brain strain: Blood flow and metabolism in environmental extremes.Experimental physiology · 2026Review
- Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study.The Journal of physiology · 2026Article
- Cerebral oxygen extraction across different exercise intensities: Role of arterialExperimental physiology · 2025Article
- Cerebral haemodynamic responses to inspiratory muscle work.Experimental physiology · 2025Article
- Cerebrovascular reactivity differences in healthy cerebral gray and white matter.Magnetic resonance in medicine · 2025Article
- Middle cerebral artery blood velocity and end-tidal carbon dioxide responses to moderate intensity cycling in children, adolescents, and adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- ln silico simulation of the interaction among autoregulatory mechanisms regulating cerebral blood flow rate in the healthy and systolic heart failure conditions during exercise.Medical & biological engineering & computing · 2022Article
- Trans-cerebral HCOJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Inspiratory threshold loading negatively impacts attentional performance.Frontiers in psychology · 2022Article
- Cerebral blood flow responses to exercise are enhanced in left ventricular assist device patients after an exercise rehabilitation program.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Matched increases in cerebral artery shear stress, irrespective of stimulus, induce similar changes in extra-cranial arterial diameter in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Heat, Hydration and the Human Brain, Heart and Skeletal Muscles.Sports medicine (Auckland, N.Z.) · 2019Review
- Effect of healthy aging and sex on middle cerebral artery blood velocity dynamics during moderate-intensity exercise.American journal of physiology. Heart and circulatory physiology · 2018Article
- The Effects of Hyperoxia on Sea-Level Exercise Performance, Training, and Recovery: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2018Review
- Cerebrovascular Function in the Large Arteries Is Maintained Following Moderate Intensity Exercise.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral blood flow (CBF) is temporally related to exercise-induced changes in partial pressure of end-tidal carbon dioxide (PetCO2 ); hyperoxia is known to enhance this relationship. We examined the hypothesis that preventing PetCO2 from rising (isocapnia) during submaximal exercise with and without hyperoxia [end-tidal Po2(PetO2 ) = 300 mmHg] would attenuate the increases in CBF. Additionally, we aimed to identify the magnitude that breathing, per se, influences the CBF response to normoxic and hyperoxic exercise. In 14 participants, CBF (intra- and extracranial) measurements were measured during exercise [20, 40, 60, and 80% of maximum workload (Wmax)] and during rest while ventilation (V̇e) was volitionally increased to mimic volumes achieved during exercise (isocapnic hyperpnea). While V̇ewas uncontrolled during poikilocapnic exercise, during isocapnic exercise and isocapnic hyperpnea, V̇ewas increased to prevent PetCO2 from rising above resting values (∼40 mmHg). Although PetCO2 differed by 2 ± 3 mmHg during normoxic poikilocapnic and isocapnic exercise, except for a greater poikilocapnic compared with isocapnic increase in blood velocity in the posterior cerebral artery at 60% Wmax, the between condition increases in intracranial (∼12-15%) and extracranial (15-20%) blood flow were similar at each workload. The poikilocapnic hyperoxic increases in both intra- and extracranial blood-flow (∼17-29%) were greater compared with poikilocapnic normoxia (∼8-20%) at intensities >40% Wmax(P< 0.01). During both normoxic and hyperoxic conditions, isocapnia normalized both the intracranial and extracranial blood-flow differences. Isocapnic hyperpnea did not alter CBF. Our findings demonstrate a differential effect of PetCO2 on CBF during exercise influenced by the prevailing PetO2.
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