ArticleEMBO reports2016
Attenuation of pattern recognition receptor signaling is mediated by a MAP kinase kinase kinase.
Article in EMBO reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Subfamily C7 Raf-like kinases MRK1, RAF26, and RAF39 regulate immune homeostasis and stomatal opening in Arabidopsis thaliana.The New phytologist · 2024Article
- Constitutive Overexpression of an NB-ARC Gene from Wild ChineseInternational journal of molecular sciences · 2024Article
- Regulatory Mechanisms of Mitogen-Activated Protein Kinase Cascades in Plants: More than Sequential Phosphorylation.International journal of molecular sciences · 2022Review
- Back From the Dead: The Atypical Kinase Activity of a Pseudokinase Regulator of Cation Fluxes During Inducible Immunity.Frontiers in plant science · 2022Article
- Appressorium-mediated plant infection by Magnaporthe oryzae is regulated by a Pmk1-dependent hierarchical transcriptional network.Nature microbiology · 2021Article
- SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A phylogenetic study of the members of the MAPK and MEK families across Viridiplantae.PloS one · 2021Article
- The overexpression of OsACBP5 protects transgenic rice against necrotrophic, hemibiotrophic and biotrophic pathogens.Scientific reports · 2020Article
- Article
- Early signalling mechanisms underlying receptor kinase-mediated immunity in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Application of targeted mass spectrometry in bottom-up proteomics for systems biology research.Journal of proteomics · 2018Review
- BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis.Plant physiology · 2018Article
- From Chaos to Harmony: Responses and Signaling upon Microbial Pattern Recognition.Annual review of phytopathology · 2017Review
- Post-translational regulation of plant immunity.Current opinion in plant biology · 2017Review
- Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition.The Plant cell · 2017Review
- A review of redox signaling and the control of MAP kinase pathway in plants.Redox biology · 2017Review
- The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation.The EMBO journal · 2016Article
- Behind the lines-actions of bacterial type III effector proteins in plant cells.FEMS microbiology reviews · 2016Review
- Regulation of pattern recognition receptor signalling in plants.Nature reviews. Immunology · 2016Review
- Attenuation of pattern recognition receptor signaling is mediated by a MAP kinase kinase kinase.EMBO reports · 2016Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pattern recognition receptors (PRRs) play a key role in plant and animal innate immunity. PRR binding of their cognate ligand triggers a signaling network and activates an immune response. Activation of PRR signaling must be controlled prior to ligand binding to prevent spurious signaling and immune activation. Flagellin perception in Arabidopsis through FLAGELLIN-SENSITIVE 2 (FLS2) induces the activation of mitogen-activated protein kinases (MAPKs) and immunity. However, the precise molecular mechanism that connects activated FLS2 to downstream MAPK cascades remains unknown. Here, we report the identification of a differentially phosphorylated MAP kinase kinase kinase that also interacts with FLS2. Using targeted proteomics and functional analysis, we show that MKKK7 negatively regulates flagellin-triggered signaling and basal immunity and this requires phosphorylation of MKKK7 on specific serine residues. MKKK7 attenuates MPK6 activity and defense gene expression. Moreover, MKKK7 suppresses the reactive oxygen species burst downstream of FLS2, suggesting that MKKK7-mediated attenuation of FLS2 signaling occurs through direct modulation of the FLS2 complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.