ArticleEMBO molecular medicine2016
IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment.
Article in EMBO molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Tumor-targeted interferon-α gene therapy for glioblastoma: a phase 1 trial.Nature medicine · 2026Trial
- Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Challenges and successes in cellular therapies and CAR-T: insights from the 50th EBMT annual meeting.Bone marrow transplantation · 2024Article
- Therapeutic utility of engineered myeloid cells in the tumor microenvironment.Cancer gene therapy · 2023Review
- Harnessing novel strategies and cell types to overcome immune tolerance during adoptive cell therapy in cancer.Journal for immunotherapy of cancer · 2023Review
- Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier.eLife · 2022Article
- Food-Grade Titanium Dioxide Induces Toxicity in the NematodeNanomaterials (Basel, Switzerland) · 2022Article
- Article
- Targeting transgenic proteins to alpha granules for platelet-directed gene therapy.Molecular therapy. Nucleic acids · 2022Article
- Myeloid cell-based delivery of IFN-γ reprograms the leukemia microenvironment and induces anti-tumoral immune responses.EMBO molecular medicine · 2021Article
- CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies.Journal for immunotherapy of cancer · 2021Article
- High-throughput microscopy reveals the impact of multifactorial environmental perturbations on colorectal cancer cell growth.GigaScience · 2021Article
- Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens.Nature communications · 2018Article
- High mobility group box 1 orchestrates tissue regeneration via CXCR4.The Journal of experimental medicine · 2018Article
- Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy.Oncotarget · 2017Review
- The adaptation of colorectal cancer cells when forming metastases in the liver: expression of associated genes and pathways in a mouse model.BMC cancer · 2017Article
- Determinants of metastatic competency in colorectal cancer.Molecular oncology · 2017Review
- IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment.EMBO molecular medicine · 2016Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) metastatic dissemination to the liver is one of the most life-threatening malignancies in humans and represents the leading cause of CRC-related mortality. Herein, we adopted a gene transfer strategy into mouse hematopoietic stem/progenitor cells to generate immune-competent mice in which TEMs-a subset of Tie2(+) monocytes/macrophages found at peritumoral sites-express interferon-alpha (IFNα), a pleiotropic cytokine with anti-tumor effects. Utilizing this strategy in mouse models of CRC liver metastasis, we show that TEMs accumulate in the proximity of hepatic metastatic areas and that TEM-mediated delivery of IFNα inhibits tumor growth when administered prior to metastasis challenge as well as on established hepatic lesions, improving overall survival. Further analyses unveiled that local delivery of IFNα does not inhibit homing but limits the early phases of hepatic CRC cell expansion by acting on the radio-resistant hepatic microenvironment. TEM-mediated IFNα expression was not associated with systemic side effects, hematopoietic toxicity, or inability to respond to a virus challenge. Along with the notion that TEMs were detected in the proximity of CRC metastases in human livers, these results raise the possibility to employ similar gene/cell therapies as tumor site-specific drug-delivery strategies in patients with CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.