ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2016
Genetic predictors of relapse rate in pediatric MS.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Why Is MS a More Frequent Complication of EBV Infection in Females?Immunological reviews · 2026Review
- Genetic Prognostic Factors in Multiple Sclerosis: Key Discoveries and Unmet Needs.International journal of molecular sciences · 2026Review
- Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Genetic influences on disease course and severity, 30 years after a clinically isolated syndrome.Brain communications · 2023Article
- Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis.Paediatric drugs · 2021Review
- Vitamin D genes influence MS relapses in children.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- Comorbidities in multiple sclerosis-a plea for interdisciplinary collaboration to improve the quality of life of MS patients.Degenerative neurological and neuromuscular disease · 2019Article
- A Scoping Review of Modifiable Risk Factors in Pediatric Onset Multiple Sclerosis: Building for the Future.Children (Basel, Switzerland) · 2018Article
- Genotype and Phenotype in Multiple Sclerosis-Potential for Disease Course Prediction?Current treatment options in neurology · 2018Review
- Pediatric multiple sclerosis: current perspectives on health behaviors.Pediatric health, medicine and therapeutics · 2018Review
- The multiple sclerosis risk allele within the AHI1 gene is associated with relapses in children and adults.Multiple sclerosis and related disorders · 2018Article
- Characteristics of Children and Adolescents With Multiple Sclerosis.Pediatrics · 2016Observational
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundGenetic ancestry, sex, and individual alleles have been associated with multiple sclerosis (MS) susceptibility.
objectiveTo determine whether established risk factors for disease onset are associated with relapse rate in pediatric MS.
methodsWhole-genome genotyping was performed for 181 MS or high-risk clinically isolated syndrome patients from two pediatric MS centers. Relapses and disease-modifying therapies were recorded as part of continued follow-up. Participants were characterized for 25-hydroxyvitamin D serum status. Ancestral estimates (STRUCTURE v2.3.1), human leukocyte antigen (HLA)-DRB1*15 carrier status (direct sequencing), sex, and a genetic risk score (GRS) of 110 non-HLA susceptibility single-nucleotide polymorphisms (SNPs) were evaluated for association with relapse rate with Cox and negative binomial regression models.
resultsOver 622 patient-years, 408 relapses were captured. Girls had greater relapse rate than boys (incident rate ratio (IRR) = 1.40, 95% confidence interval (CI) = 1.04-1.87, p = 0.026). Participants were genetically diverse; ~40% (N = 75) had <50% European ancestry. HLA-DRB1*15 status modified the association of vitamin D status (p
conclusionWe demonstrate that HLA-DRB1*15 modifies the association of vitamin D status with relapse rate. Our findings emphasize the need to pursue disease-modifying effects of MS genes in the context of environmental factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.