SynthesisArchives of disease in childhood2016
Systematic review of the toxicity of short-course oral corticosteroids in children.
Synthesis in Archives of disease in childhood, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04828525 (Corticosteroids as an Additional Treatment for Mastoiditis In Children), which is not on this map. Cited by 55 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Corticosteroids as an Additional Treatment for Mastoiditis In Children
Who cites it
55 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- A systematic review of adverse effects associated with systemic corticosteroids in the management of leprosy.PLoS neglected tropical diseases · 2026Pooled it
- Efficacy and Safety of Colchicine in Pediatric Pericarditis: A Systematic Review and Future Directions.Pediatric cardiology · 2025Pooled it
- Adverse Events Following Short-Course Systemic Corticosteroids Among Children and Adolescents: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Corticosteroids for septic arthritis in children.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Olaparib Blocks Oxidative Stress-Dependent NLRP3 Inflammasome in Pediatric Acute Lung Injury by Metabolic Reprogramming via AMPK-Driven Autophagic Flux.The Kaohsiung journal of medical sciences · 2026Article
- Abrocitinib for pediatric Toxicodendron contact dermatitis.JAAD case reports · 2026Article
- Revisiting the safety of short-term systemic corticosteroids.Biomedical journal · 2026Review
- Real-world impact of mepolizumab on pediatric and adolescent patients with severe asthma.The journal of allergy and clinical immunology. Global · 2026Article
- Estimation of short-course systemic corticosteroid risks on adverse outcomes in childhood asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- State of art of oral corticosteroids in children with acute asthma and wheezing.Italian journal of pediatrics · 2026Review
- Real-world effectiveness and safety of dupilumab therapy in children ≤6 years with uncontrolled persistent asthma: a propensity-matched retrospective cohort study.Frontiers in pediatrics · 2026Article
- Association of systemic corticosteroids and clinical outcomes in children hospitalised with severe orbital infections.BMJ paediatrics open · 2025Observational
- Impact of glucocorticoid therapy on hypothalamic-pituitary-adrenal axis function in pediatric nephrotic syndrome: A narrative review.World journal of clinical pediatrics · 2025Review
- The burden of systemic corticosteroids in patients with chronic rhinosinusitis with nasal polyps.Allergy and asthma proceedings · 2025Review
- Real-world evidence on biologic use in paediatric asthma: there but not there yet?ERJ open research · 2025Article
- Intravenous Dexamethasone Use and Outcomes in Children Hospitalized With Septic Arthritis.Hospital pediatrics · 2025Article
- Short Course of Systemic Steroids for Acute Respiratory Diseases During Infancy and Final Adult Height, Weight, and BMI: Preliminary Results from a Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundShort-course oral corticosteroids are commonly used in children but are known to be associated with adverse drug reactions (ADRs). This review aimed to identify the most common and serious ADRs and to determine their relative risk levels.
methodsA literature search of EMBASE, MEDLINE, International Pharmaceutical Abstracts, CINAHL, Cochrane Library and PubMed was performed with no language restrictions to identify studies in which oral corticosteroids were administered to patients aged 28 days to 18 years of age for up to and including 14 days of treatment. Each database was searched from their earliest dates to December 2013. All studies providing clear information on ADRs were included.
resultsThirty-eight studies including 22 randomised controlled trials (RCTs) met the inclusion criteria. The studies involved a total of 3200 children in whom 850 ADRs were reported. The three most frequent ADRs were vomiting, behavioural changes and sleep disturbance, with respective incidence rates of 5.4%, 4.7% and 4.3% of patients assessed for these ADRs. Infection was one of the most serious ADRs; one child died after contracting varicella zoster. When measured, 144 of 369 patients showed increased blood pressure; 21 of 75 patients showed weight gain; and biochemical hypothalamic-pituitary-adrenal axis suppression was detected in 43 of 53 patients.
conclusionsVomiting, behavioural changes and sleep disturbance were the most frequent ADRs seen when short-course oral corticosteroids were given to children. Increased susceptibility to infection was the most serious ADR. TRIAL REGISTRATION NUMBER: CRD42014008774. By PROSPERO International prospective register of systematic reviews.
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