Evidence map›Paper›PMID 26768791›Full record

ReviewFuture oncology (London, England)2016

Biomarkers in localized prostate cancer.

Matteo Ferro, Carlo Buonerba, Daniela Terracciano, Giuseppe Lucarelli, Vincenzo Cosimato, Danilo Bottero, Victor M Deliu, Pasquale Ditonno, Sisto Perdonà, Riccardo Autorino and 4 more

Abstract readReview
In one paragraph

Review in Future oncology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Biomarkers in Localized Prostate Cancer: From Diagnosis to Treatment.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Review
  6. microRNA-205 in prostate cancer: Overview to clinical translation.Biochimica et biophysica acta. Reviews on cancer · 2022
    Review
  7. Review
  8. Article
  9. Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Prostate Cancer Radiogenomics-From Imaging to Molecular Characterization.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Matteo FerroDivision of Urology, European Institute of Oncology, Milan, Italy.
Carlo BuonerbaMedical Oncology, Department of Clinical Medicine & Surgery, University 'Federico II', Naples, Italy.
Daniela TerraccianoDepartment of Translational Medical Sciences, University 'Federico II', Naples, Italy.
Giuseppe LucarelliDepartment of Emergency & Organ Transplantation - Urology, Andrology & Kidney Transplantation Unit, University of Bari, Bari, Italy.
Vincenzo CosimatoDepartment of Translational Medical Sciences, University 'Federico II', Naples, Italy.
Danilo BotteroDivision of Urology, European Institute of Oncology, Milan, Italy.
Victor M DeliuDivision of Urology, European Institute of Oncology, Milan, Italy.
Pasquale DitonnoDepartment of Emergency & Organ Transplantation - Urology, Andrology & Kidney Transplantation Unit, University of Bari, Bari, Italy.
Sisto PerdonàDepartment of Urology, National Cancer Institute of Naples, Naples, Italy.
Riccardo AutorinoUrology Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.
Ioman ComanDepartment of Urology 'Iuliu Hatieganu', University of Medicine & Pharmacy, 400012 Cluj-Napoca, Romania.
Sabino De PlacidoMedical Oncology, Department of Clinical Medicine & Surgery, University 'Federico II', Naples, Italy.
Giuseppe Di LorenzoMedical Oncology, Department of Clinical Medicine & Surgery, University 'Federico II', Naples, Italy.
Ottavio De CobelliDivision of Urology, European Institute of Oncology, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers can improve prostate cancer diagnosis and treatment. Accuracy of prostate-specific antigen (PSA) for early diagnosis of prostate cancer is not satisfactory, as it is an organ- but not cancer-specific biomarker, and it can be improved by using models that incorporate PSA along with other test results, such as prostate cancer antigen 3, the molecular forms of PSA (proPSA, benign PSA and intact PSA), as well as kallikreins. Recent reports suggest that new tools may be provided by metabolomic studies as shown by preliminary data on sarcosine. Additional molecular biomarkers have been identified by the use of genomics, proteomics and metabolomics. We review the most relevant biomarkers for early diagnosis and management of localized prostate cancer.

Indexed as

DNA MethylationEarly Detection of CancerHumansMaleMicroRNAsOncogene Proteins, FusionProstateProstate-Specific AntigenProstatic NeoplasmsSarcosineTreatment OutcomeMicroRNAsOncogene Proteins, FusionProstate-Specific AntigenSarcosinebiomarkersprostate cancer

Identifiers

PMID26768791
PMCPMC5549774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.