ArticleCell research2016
Anti-cancer effects of vitamin C revisited.
Article in Cell research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- The effect of circulating micronutrients on nasopharyngeal carcinoma: A Mendelian randomization study.Medicine · 2025Article
- Genetics aspect of vitamin C (Ascorbic Acid) biosynthesis and signaling pathways in fruits and vegetables crops.Functional & integrative genomics · 2024Review
- Micronutrients Importance in Cancer Prevention-Vitamins.Cancer treatment and research · 2024Review
- Biodistribution and radiation dosimetry in cancer patients of the ascorbic acid analogue 6-Deoxy-6-[European journal of nuclear medicine and molecular imaging · 2023Article
- Updated Perspectives on the Diagnosis and Management of Familial Adenomatous Polyposis.The application of clinical genetics · 2023Review
- The Anti-Leukemia Effect of Ascorbic Acid: From the Pro-Oxidant Potential to the Epigenetic Role in Acute Myeloid Leukemia.Frontiers in cell and developmental biology · 2022Review
- A guide to plasma membrane solute carrier proteins.The FEBS journal · 2021Review
- Pharmacological Vitamin C Treatment Impedes the Growth of Endogenous Glutamine-Dependent Cancers by Targeting Glutamine Synthetase.Frontiers in pharmacology · 2021Article
- Chemoprevention in familial adenomatous polyposis: past, present and future.Familial cancer · 2021Review
- Prophylactic Treatment with Vitamins C and B2 for Methotrexate-Induced Gastrointestinal Mucositis.Biomolecules · 2020Article
- Effects of vitamin C on osteoblast proliferation and osteosarcoma inhibition using plasma coated hydroxyapatite on titanium implants.Surface & coatings technology · 2020Article
- Vitamin C Loaded Polyethylene: Synthesis and Properties of Precise Polyethylene with Vitamin C Defects via Acyclic Diene Metathesis Polycondensation.Macromolecules · 2020Article
- Synergistic Effect of Vitamin C with Cisplatin for Inhibiting Proliferation of Gastric Cancer CellsIranian biomedical journal · 2020Article
- Vitamin C Inhibits Metastasis of Peritoneal Tumors By Preventing Spheroid Formation in ID8 Murine Epithelial Peritoneal Cancer Model.Frontiers in pharmacology · 2020Article
- High-Dose Vitamin C Tends to Kill Colorectal Cancer with High MALAT1 Expression.Journal of oncology · 2020Article
- 2-O-β-d-glucopyranosyl-Redox biology · 2019Article
- Citric Juice-mediated Synthesis of Tellurium Nanoparticles with Antimicrobial and Anticancer Properties.Green chemistry : an international journal and green chemistry resource : GC · 2019Article
- Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging.Biology · 2019Review
- Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations.Oxidative medicine and cellular longevity · 2019Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Vitamin C was first suggested to have cancer-fighting properties in the 1930s and has been the subject of controversy ever since. Despite repeated reports of selective cancer cell toxicity induced by high-dose vitamin C treatment in vitro and in mouse models, the mechanism of action has remained elusive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.