Evidence map›Paper›PMID 26768584›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2016

Individualized significance of the -251 A/T single nucleotide polymorphism of interleukin-8 in severe infections.

M D Georgitsi, V Vitoros, C Panou, I Tsangaris, E Aimoniotou, N K Gatselis, E Chasou, G Kouliatsis, K Leventogiannis, D Velissaris and 10 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 2 countries.

M D Georgitsi4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece.
V Vitoros1st Department of Internal Medicine, Thriasion Elefsis General Hospital, Elefsis, Greece.
C PanouDepartment of Urology, Lamia General Hospital, Lamia, Greece.
I Tsangaris2nd Department of Critical Care Medicine, University of Athens, Medical School, Athens, Greece.
E AimoniotouIntensive Care Unit, Aghios Dimitrios General Hospital, Thessaloniki, Greece.
N K GatselisDepartment of Medicine and Research Laboratory of Internal Medicine, Medical School, University of Thessaly, Larissa, Greece.
E ChasouIntensive Care Unit, "G.Gennimatas" General Hospital, Thessaloniki, Greece.
G KouliatsisDepartment of Critical Care Medicine, University of Thrace, Medical School, Alexandroupolis, Greece.
K Leventogiannis4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece.
D VelissarisDepartment of Internal Medicine, University of Patras, Patras, Greece.
E BelesiotouDepartment of Clinical Microbiology, Evangelismos General Hospital, Athens, Greece.
O Dioritou-AggaliadouIntensive Care Unit, Aghios Pavlos General Hospital, Thessaloniki, Greece.
E Giannitsioti4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece.
M G NeteaDepartment of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
E J Giamarellos-Bourboulis4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece. egiamarel@med.uoa.gr.
G GiannikopoulosDepartment of Internal Medicine, Chios General Hospital, Chios, Greece.
Z Alexiou2nd Department of Internal Medicine, Thriasion Elefsis General Hospital, Elefsis, Greece.
N Voloudakis2nd Department of Surgery, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
A Koutsoukou1st Department of Respiratory Medicine, University of Athens, Medical School, Athens, Greece.
Hellenic Sepsis Study Group
National and Kapodistrian University of Athens · GRRadboud University Nijmegen · NLTechnological Educational Institute of Central Greece · GRUniversity of Patras · GRUniversity of Thessaly · GRAgios Pavlos General Hospital · GRAristotle University of Thessaloniki · GRGeneral Hospital of Athens G. Genimatas · GRThriasio General Hospital of Elefsina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on the concept of the individualized nature of sepsis, we investigated the significance of the -251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentAdultAgedAged, 80 and overBacterial InfectionsFemaleGenotypeHumansInterleukin-8MaleMiddle AgedYoung AdultInterleukin-8

Identifiers

PMID26768584
OpenAlexW2239446968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.