Evidence map›Paper›PMID 26768394›Full record

Observational studyThe Gerontologist2016

Fracture Rates and Bone Density Among Postmenopausal Veteran and Non-Veteran Women From the Women's Health Initiative.

Joanne LaFleur, Eileen Rillamas-Sun, Cathleen S Colón-Emeric, Kristin A Knippenberg, Kristine E Ensrud, Shelly L Gray, Jane A Cauley, Andrea Z LaCroix

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in The Gerontologist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications.The Journal of clinical endocrinology and metabolism · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Joanne LaFleurVA Salt Lake City Healthcare System, Utah. Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake City. Joanne.LaFleur@va.gov.
Eileen Rillamas-SunDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Cathleen S Colón-EmericDurham Center for Health Services Research and Durham Geriatric Research, Education and Clinical Center, Department of Veterans Affairs, North Carolina. Department of Medicine, Duke University, Durham, North Carolina.
Kristin A KnippenbergVA Salt Lake City Healthcare System, Utah. Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake City.
Kristine E EnsrudCenter for Chronic Disease Outcomes Research, Minneapolis VA Health Care System, One Veterans Drive, Minnesota. Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis.
Shelly L GraySchool of Pharmacy, University of Washington, Seattle.
Jane A CauleyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
Andrea Z LaCroixDivision of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego, La Jolla.
Fred Hutch Cancer Center · USUniversity of California, San Diego · USUniversity of Pittsburgh · USUniversity of Washington · US

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Sarah B. Peskoe · 2006 to 2026
$24.6M
Knowledge engineering for decision support in osteoporosisK08HS018582 · AHRQ · UNIVERSITY OF UTAH · PI LAFLEUR, JOANNE FRANCOISE · 2009 to 2013
$787k
Mentoring Intervention Development in Fall and Fracture PreventionK24AG049077 · NIA · DUKE UNIVERSITY · PI COLON-EMERIC, CATHLEEN S · 2015 to 2019
$361k
AHRQ HHS K08HS018582NIA NIH HHS K24 AG049077NIA NIH HHS P30 AG028716
6 · The paper itself

Abstract

purpose of the studyPostmenopausal osteoporosis can impact quality-of-life even prefracture. To determine whether osteoporosis should be a greater concern in women Veterans versus non-Veterans, we compared fracture rates and bone mineral density (BMD) for Veterans and non-Veterans using Women's Health Initiative data. DESIGN AND

methodsIn this cohort study, participants were women aged 50-79 years. Outcomes were hip, central body, and limb fractures occurring during up to 19 years of follow-up and hip, spine, and whole body BMD collected three times over a 6-year period in a participant subsample. Covariates comprised risk factors for fracture, including fall history and other components of the World Health Organization Fracture Risk Assessment Tool (FRAX). Cox Proportional Hazards models were used to examine fracture rates for Veterans compared with non-Veterans.

resultsOf 161,808 women, 145,521 self-identified as Veteran (n = 3,719) or non-Veteran (n = 141,802). Baseline FRAX scores showed that Veterans had higher 10-year probabilities for any major fracture (13.3 vs 10.2; p < .01) and hip fracture (4.1 vs 2.2; p < .01) compared with non-Veterans. The age-adjusted rate of hip fracture per 1,000 person-years for Veterans was 3.3 versus 2.4 for non-Veterans (p < .01). After adjustment, the hazards ratio for hip fracture was 1.24 (95% confidence interval 1.03-1.49) for Veterans versus non-Veterans. Hazards ratios at other anatomic sites did not differ by Veteran status. Mean BMD at baseline and at Years 3 and 6 also did not differ by Veteran status at any site. IMPLICATIONS: Women Veterans had an increased hip fracture rate not explained by differences in well-recognized fracture risk factors.

Indexed as

Bone DensityPostmenopauseAbsorptiometry, PhotonAgedAged, 80 and overAlcohol DrinkingCase-Control StudiesCohort StudiesEstrogen Replacement TherapyFemaleFractures, BoneHipHumansIncidenceMiddle AgedOsteoporosis, PostmenopausalCohortFractureOsteoporosisPostmenopausal osteoporosisRisk factorsVeterans

Identifiers

PMID26768394
PMCPMC4759700
OpenAlexW2305676357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.