Evidence map›Paper›PMID 26768270›Full record

ReviewZeitschrift fur Rheumatologie2016

[Medication treatment of rheumatoid arthritis with a history of malignancy. Epidemiological data].

M Schmalzing, A Strangfeld, H-P Tony

Abstract readReview
PubMed Publisher
In one paragraph

Review in Zeitschrift fur Rheumatologie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

M SchmalzingRheumatologie/klinische Immunologie, Medizinische Klinik und Poliklinik 2, Zentrum Innere Medizin, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland. schmalzing_m@ukw.de.
A StrangfeldProgrammbereich Epidemiologie, Gruppe Pharmakoepidemiologie, DRFZ - Deutsches Rheuma-Forschungszentrum, Charitéplatz 1, 10117, Berlin, Deutschland.
H-P TonyRheumatologie/klinische Immunologie, Medizinische Klinik und Poliklinik 2, Zentrum Innere Medizin, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOnly insufficient data are available regarding the question whether treatment with immunosuppressants or biologicals is feasible and safe in patients with a history of malignancy.

methodLiterature search via PubMed, EULAR abstracts and ACR abstracts from 2013 to 2015.

resultsThe Société Francaise de Rhumatologie, the Canadian Rheumatology Association and the American College of Rheumatology have tried to make recommendations on this topic. Direct evidence mainly originates from data in three national registries which suggest that treatment with tumor necrosis factor (TNF) inhibitors and rituximab appears to be safe for carefully selected patients, at least if there is a longer interval between treatment with biologicals and oncological treatment. Furthermore, despite partly conflicting data all routine drugs for treating rheumatoid arthritis do not seem to show a consistently increased risk of de novo malignancies. The currently available data are presented for each drug of interest.

conclusionTaking the current literature into account an attempt is made to formulate an algorithm for the medicinal treatment of patients with rheumatoid arthritis and a history of malignancy.

Indexed as

AlgorithmsAntirheumatic AgentsArthritis, RheumatoidCanadaComorbidityDrug-Related Side Effects and Adverse ReactionsEvidence-Based MedicineHumansNeoplasmsPrevalenceRisk AssessmentRisk FactorsTreatment OutcomeUnited StatesAntirheumatic AgentsBiologicsImmunosuppressionRegistriesRituximabTNF inhibitors

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.