ReviewEnvironmental health : a global access science source2016
Risks associated with endotoxins in feed additives produced by fermentation.
Review in Environmental health : a global access science source, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- The Devil Lies in the Details: Small Structural and Chemical Changes in Iron Oxide Pigments Largely Alter the Biological Outcomes in Macrophages.Nanomaterials (Basel, Switzerland) · 2025Article
- A single-vector CRISPR/Cas9 system for genome editing and heterologous enzyme secretion in Saccharomyces cerevisiae: a case study on pectate lyase for coffee mucilage removal.Biotechnology letters · 2025Article
- Bioaerosols and Airway Diseases: Mechanisms of Epithelial Dysfunction, Immune Activation, and Strategies for Exposure Mitigation.Archives of internal medicine research · 2025Article
- Engineering a high-sugar tolerant strain of Saccharomyces cerevisiae for efficient trehalose production using a cell surface display approach.Bioresources and bioprocessing · 2024Article
- Safety and efficacy of a feed additive consisting of vitamin BEFSA journal. European Food Safety Authority · 2024Article
- Endotoxin content in neonatal formulas, fortification, and lactoferrin products: association with outcomes and guidance on acceptable limits.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Safety and efficacy of a feed additive consisting of vitamin B12 (cyanocobalamin) produced by fermentation withEFSA journal. European Food Safety Authority · 2023Article
- Post-endotoxin exposure-induced lung inflammation and resolution consequences beneficially impacted by lung-delivered IL-10 therapy.Scientific reports · 2022Article
- Assessment of Indoor Air Quality for Group-Housed Macaques (Animals : an open access journal from MDPI · 2022Article
- Article
- Safety and efficacy of a feed additive consisting of l-histidine monohydrochloride monohydrate produced usingEFSA journal. European Food Safety Authority · 2021Article
- Effect of Food Endotoxin on Infant Health.Toxins · 2021Review
- Safety of vitamin BEFSA journal. European Food Safety Authority · 2020Article
- Safety and Efficacy of l-histidine monohydrochloride monohydrate produced by fermentation usingEFSA journal. European Food Safety Authority · 2020Article
- Safety and efficacy of l-valine produced by fermentation usingEFSA journal. European Food Safety Authority · 2020Article
- Safety and efficacy of l-tryptophan produced withEFSA journal. European Food Safety Authority · 2019Article
- Dietary deoxynivalenol and oral lipopolysaccharide challenge differently affect intestinal innate immune response and barrier function in broiler chickens.Journal of animal science · 2018Article
- Safety and efficacy of vitamin BEFSA journal. European Food Safety Authority · 2018Article
- Airborne bioaerosols and their impact on human health.Journal of environmental sciences (China) · 2018Review
- Design of a Type-1 Diabetes Vaccine Candidate Using Edible Plants Expressing a Major Autoantigen.Frontiers in plant science · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 9 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasingly, feed additives for livestock, such as amino acids and vitamins, are being produced by Gram-negative bacteria, particularly Escherichia coli. The potential therefore exists for animals, consumers and workers to be exposed to possibly harmful amounts of endotoxin from these products. The aim of this review was to assess the extent of the risk from endotoxins in feed additives and to calculate how such risk can be assessed from the properties of the additive. Livestock are frequently exposed to a relatively high content of endotoxin in the diet: no additional hazard to livestock would be anticipated if the endotoxin concentration of the feed additive falls in the same range as feedstuffs. Consumer exposure will be unaffected by the consumption of food derived from animals receiving endotoxin-containing feed, because the small concentrations of endotoxin absorbed do not accumulate in edible tissues. In contrast, workers processing a dusty additive may be exposed to hazardous amounts of endotoxin even if the endotoxin concentration of the product is low. A calculation method is proposed to compare the potential risk to the worker, based on the dusting potential, the endotoxin concentration and technical guidance of the European Food Safety Authority, with national exposure limits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.