ArticleAlzheimer's research & therapy2016
Reference tissue normalization in longitudinal (18)F-florbetapir positron emission tomography of late mild cognitive impairment.
Article in Alzheimer's research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 18F PET with florbetapir for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).The Cochrane database of systematic reviews · 2017Pooled it
- Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE).Alzheimer's research & therapy · 2018Trial
- Brain maintenance biomarkers from structural and functional interactions in aging and neurodegeneration.Nature communications · 2026Article
- The associations between synaptic density and "A/T/N" biomarkers in Alzheimer's disease: AnJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Multi-domain cognition dysfunction accompanies frontoparietal and temporal amyloid accumulation in the elderly.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer's Disease.Scientific data · 2023Article
- The RSNA QIBA Profile for Amyloid PET as an Imaging Biomarker for Cerebral Amyloid Quantification.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Tracer-specific reference tissues selection improves detection ofHuman brain mapping · 2022Article
- Self-normalized Classification of Parkinson's Disease DaTscan Images.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2021Article
- Spatially constrained kinetic modeling with dual reference tissues improvesEuropean journal of nuclear medicine and molecular imaging · 2021Article
- AMYQ: An index to standardize quantitative amyloid load across PET tracers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring.International journal of molecular sciences · 2021Review
- Blinded Clinical Evaluation for Dementia of Alzheimer's Type Classification Using FDG-PET: A Comparison Between Feature-Engineered and Non-Feature-Engineered Machine Learning Methods.Journal of Alzheimer's disease : JAD · 2021Article
- Parametric estimation of reference signal intensity in the quantification of amyloid-beta deposition: anQuantitative imaging in medicine and surgery · 2021Article
- Evaluation of the early-phase [NeuroImage. Clinical · 2021Article
- Quantification of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Investigation of white matter PiB uptake as a marker of white matter integrity.Annals of clinical and translational neurology · 2019Article
- Association of short-term cognitive decline and MCI-to-AD dementia conversion with CSF, MRI, amyloid- andNeuroImage. Clinical · 2019Article
- White Matter Reference Region in PET Studies ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
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10 authors.
Funding
Abstract
backgroundSemiquantitative methods such as the standardized uptake value ratio (SUVR) require normalization of the radiotracer activity to a reference tissue to monitor changes in the accumulation of amyloid-β (Aβ) plaques measured with positron emission tomography (PET). The objective of this study was to evaluate the effect of reference tissue normalization in a test-retest (18)F-florbetapir SUVR study using cerebellar gray matter, white matter (two different segmentation masks), brainstem, and corpus callosum as reference regions.
methodsWe calculated the correlation between (18)F-florbetapir PET and concurrent cerebrospinal fluid (CSF) Aβ1-42 levels in a late mild cognitive impairment cohort with longitudinal PET and CSF data over the course of 2 years. In addition to conventional SUVR analysis using mean and median values of normalized brain radiotracer activity, we investigated a new image analysis technique-the weighted two-point correlation function (wS2)-to capture potentially more subtle changes in Aβ-PET data.
resultsCompared with the SUVRs normalized to cerebellar gray matter, all cerebral-to-white matter normalization schemes resulted in a higher inverse correlation between PET and CSF Aβ1-42, while the brainstem normalization gave the best results (high and most stable correlation). Compared with the SUVR mean and median values, the wS2 values were associated with the lowest coefficient of variation and highest inverse correlation to CSF Aβ1-42 levels across all time points and reference regions, including the cerebellar gray matter.
conclusionsThe selection of reference tissue for normalization and the choice of image analysis method can affect changes in cortical (18)F-florbetapir uptake in longitudinal studies.
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