ArticleNeurogastroenterology and motility2016
Esophagogastric junction contractile integral (EGJ-CI) quantifies changes in EGJ barrier function with surgical intervention.
Article in Neurogastroenterology and motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Guideline
- High-Resolution Manometry in Treated Achalasia: Scoping Review and Novel Nomenclature.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
- Changes in esophageal contractile and barrier function in lung transplant recipients.Esophagus : official journal of the Japan Esophageal Society · 2025Article
- Utilizing Esophageal Motility Tests in Diagnosing and Evaluating Gastroesophageal Reflux Disease.Diagnostics (Basel, Switzerland) · 2024Review
- Novel Diagnostic Techniques in the Evaluation of Gastroesophageal Reflux Disease (GERD).Digestive diseases and sciences · 2023Review
- Concise Review: Applicability of High-resolution Manometry in Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2022Review
- Esophageal manometry findings in patients with refractory symptoms of gastroesophageal reflux disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Article
- Chicago Classification update (v4.0): Technical review of high-resolution manometry metrics for EGJ barrier function.Neurogastroenterology and motility · 2021Article
- Diagnosis and Management of Refractory Gastroesophageal Reflux Disease.Gastroenterology & hepatology · 2021Article
- Esophagogastric junction morphology and contractile integral on high-resolution manometry in asymptomatic healthy volunteers: An international multicenter study.Neurogastroenterology and motility · 2021Article
- Different Effects of Aerobic Exercise and Diaphragmatic Breathing on Lower Esophageal Sphincter Pressure and Quality of Life in Patients with Reflux: A Comparative Study.Middle East journal of digestive diseases · 2021Article
- Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0Neurogastroenterology and motility · 2021Review
- Current Advancement on the Dynamic Mechanism of Gastroesophageal Reflux Disease.International journal of biological sciences · 2021Review
- Reduced Esophageal Contractility Is Associated with Dysplasia Progression in Barrett's Esophagus: A Multicenter Cohort Study.Digestive diseases and sciences · 2020Article
- The Utility of Esophageal Motility Testing in Gastroesophageal Reflux Disease (GERD).Current gastroenterology reports · 2019Review
- Advances in the Diagnosis and Treatment of GERD: New Tricks for an Old Disease.Current treatment options in gastroenterology · 2019Review
- A study of dysphagia symptoms and esophageal body function in children undergoing anti-reflux surgery.United European gastroenterology journal · 2018Article
- Review
- A modified Nissen fundoplication: subjective and objective midterm results.Langenbeck's archives of surgery · 2018Article
- The Esophageal Manometry with Gas-perfused Catheters.Open medicine (Warsaw, Poland) · 2018Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEsophagogastric junction contractile integral (EGJ-CI) assesses EGJ barrier function on esophageal high resolution manometry (HRM). We assessed EGJ-CI values in achalasia and gastroesophageal reflux disease (GERD) to determine if postoperative EGJ-CI changes reflected surgical intervention.
methodsTwenty-one achalasia patients (42.8 ± 3.2 years, 62% F) with HRM before and after Heller myotomy (HM) and 68 GERD patients (53.9 ± 1.8 years, 66% F) undergoing antireflux surgery (ARS) were compared to 21 healthy controls (27.6 ± 0.6 years, 52% F). Esophagogastric junction contractile integral (mmHg.cm) was calculated using the distal contractile integral measurement across the EGJ, measured above the gastric baseline and corrected for respiration. Pre and postsurgical EGJ-CI and conventional lower esophageal sphincter pressure (LESP) metrics were compared within and between these groups using non-parametric tests. Correlation between EGJ-CI and conventional LESP metrics was assessed. KEY
resultsBaseline EGJ-CI was higher in achalasia compared to GERD (p < 0.001) or controls (p = 0.03). Esophagogastric junction contractile integral declined by 59.2% after HM in achalasia (p = 0.001), and increased by 26.3% after ARS in GERD (p = 0.005). End-expiratory and basal LESP decreased by 74.5% and 64.5% with HM, but increased by only 17.8% and 4.3% with ARS. Differences were noted between Dor vs Toupet fundoplication in achalasia (p = 0.007), and partial vs complete ARS in GERD (p = 0.03). Esophagogastric junction contractile integral correlated modestly with both end-expiratory and basal LESP (Pearson's r of 0.8 for all), but was less robust in GERD (0.7). CONCLUSIONS & INFERENCES: Esophagogastric junction contractile integral has clinical utility in assessing EGJ barrier function at baseline and after surgical intervention to the EGJ, and could complement conventional EGJ metrics.
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