ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2016
Predicting the activation states of the muscles governing upper esophageal sphincter relaxation and opening.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Defining Pharyngeal and Upper Esophageal Sphincter Disorders on High-Resolution Manometry-Impedance: The Leuven Consensus.Neurogastroenterology and motility · 2026Article
- Impact of rTMS and iTBS on Cerebral Hemodynamics and Swallowing in Unilateral Stroke: Insights from fNIRS.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Defining lower esophageal sphincter physiomechanical states among esophageal motility disorders using functional lumen imaging probe panometry.Neurogastroenterology and motility · 2024Article
- A Mechanics-Based Perspective on the Function of Human Sphincters During Functional Luminal Imaging Probe Manometry.Journal of biomechanical engineering · 2024Article
- Clinical Significance of Surgical Intervention to Restore Swallowing Function for Sustained Severe Dysphagia.Journal of clinical medicine · 2023Article
- A mechanics-based perspective on the function of the esophagogastric junction during functional luminal imaging probe manometry.Biomechanics and modeling in mechanobiology · 2023Article
- Normative values of intra-bolus pressure and esophageal compliance based on 4D high-resolution impedance manometry.Neurogastroenterology and motility · 2022Article
- Effect of Tongue-Hold Swallow on Pharyngeal Contractile Properties in Healthy Individuals.Dysphagia · 2021Article
- Review
- The Mendelsohn Maneuver and its Effects on Swallowing: Kinematic Analysis in Three Dimensions Using Dynamic Area Detector CT.Dysphagia · 2018Article
- Modulation of Upper Esophageal Sphincter (UES) Relaxation and Opening During Volume Swallowing.Dysphagia · 2017Article
- Diagnosis of Swallowing Disorders: How We Interpret Pharyngeal Manometry.Current gastroenterology reports · 2017Review
- Pharyngeal Pressure and Timing During Bolus Transit.Dysphagia · 2017Article
- Advances with Neonatal Aerodigestive Science in the Pursuit of Safe Swallowing in Infants: Invited Review.Dysphagia · 2017Review
- Therapeutic intervention in oropharyngeal dysphagia.Nature reviews. Gastroenterology & hepatology · 2016Review
- Dysphagia Practice in 2035: Beyond Fluorography, Thickener, and Electrical Stimulation.Seminars in speech and language · 2016Article
- Characterization of Esophageal Physiology Using Mechanical State Analysis.Frontiers in systems neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The swallowing muscles that influence upper esophageal sphincter (UES) opening are centrally controlled and modulated by sensory information. Activation and deactivation of neural inputs to these muscles, including the intrinsic cricopharyngeus (CP) and extrinsic submental (SM) muscles, results in their mechanical activation or deactivation, which changes the diameter of the lumen, alters the intraluminal pressure, and ultimately reduces or promotes flow of content. By measuring the changes in diameter, using intraluminal impedance, and the concurrent changes in intraluminal pressure, it is possible to determine when the muscles are passively or actively relaxing or contracting. From these "mechanical states" of the muscle, the neural inputs driving the specific motor behaviors of the UES can be inferred. In this study we compared predictions of UES mechanical states directly with the activity measured by electromyography (EMG). In eight subjects, pharyngeal pressure and impedance were recorded in parallel with CP- and SM-EMG activity. UES pressure and impedance swallow profiles correlated with the CP-EMG and SM-EMG recordings, respectively. Eight UES muscle states were determined by using the gradient of pressure and impedance with respect to time. Guided by the level and gradient change of EMG activity, mechanical states successfully predicted the activity of the CP muscle and SM muscle independently. Mechanical state predictions revealed patterns consistent with the known neural inputs activating the different muscles during swallowing. Derivation of "activation state" maps may allow better physiological and pathophysiological interpretations of UES function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.