ArticleLab on a chip2016
Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.
Article in Lab on a chip, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Tunable Particle Separation in a Straight Microchannel via Symmetrical Viscoelastic Sheath Flows.Biosensors · 2026Article
- Blood component separation in straight microfluidic channels.Biomicrofluidics · 2023Article
- Point of care technologies for sepsis diagnosis and treatment.Lab on a chip · 2019Review
- Acoustic impedance matched buffers enable separation of bacteria from blood cells at high cell concentrations.Scientific reports · 2018Article
- Enhanced separation of aged RBCs by designing channel cross section.Biomicrofluidics · 2018Article
- The Continuous Concentration of Particles and Cancer Cell Line Using Cell Margination in a Groove-Based Channel.Micromachines · 2017Article
- Rapid separation of very low concentrations of bacteria from blood.Journal of microbiological methods · 2017Article
- Rapid separation of bacteria from blood - Chemical aspects.Colloids and surfaces. B, Biointerfaces · 2017Article
- Monitoring sepsis using electrical cell profiling.Lab on a chip · 2016Article
- Rapid separation of bacteria from blood-review and outlook.Biotechnology progress · 2016Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Sepsis represents a systemic inflammatory response caused by microbial infection in blood. Herein, we present a novel comprehensive approach to mitigate inflammatory responses through broad spectrum removal of pathogens, leukocytes and cytokines based on biomimetic cell margination. Using a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP), we performed extracorporeal blood filtration with the developed microfluidic blood margination (μBM) device. Circulating bacteremia, leukocytes and cytokines in blood decreased post-filtration and significant attenuation of immune cell and cytokine responses were observed 3-5 days after intervention, indicating successful long-term immunomodulation. A dose-dependent effect on long-term immune cell count was also achieved by varying filtration time. As proof of concept for human therapy, the μBM device was scaled up to achieve ∼100-fold higher throughput (∼150 mL h(-1)). With further multiplexing, the μBM technique could be applied in clinical settings as an adjunctive treatment for sepsis and other inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.