ReviewThe Korean journal of internal medicine2016
Breakthrough in heart failure with preserved ejection fraction: are we there yet?
Review in The Korean journal of internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- The vasculature: a therapeutic target in heart failure?Cardiovascular research · 2022Review
- Immunomodulation in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives.Journal of cardiovascular translational research · 2021Review
- Attitudes toward advance directives and prognosis in patients with heart failure: a pilot study.The Korean journal of internal medicine · 2020Article
- Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.Journal of cellular physiology · 2019Review
- Vasodilation and Reduction of Systolic Blood Pressure after One Session of High-Intensity Interval Training in Patients With Heart Failure with Preserved Ejection Fraction.Arquivos brasileiros de cardiologia · 2018Article
- Palliative and end-of-life care for heart failure patients in an aging society.The Korean journal of internal medicine · 2018Review
- Concomitant diastolic dysfunction further interferes with cognitive performance in moderate to severe systolic heart failure.PloS one · 2017Article
- Commentary: Heart Failure with Preserved Ejection Fraction Induces Beiging in Adipose Tissue.Frontiers in physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective therapies underscores our incomplete understanding of this complex heterogeneous syndrome. A novel paradigm has recently emerged, in which central roles are ascribed to systemic inflammation and generalized endothelial dysfunction in the pathophysiology of HFPEF. In this review, we discuss the role of the endothelium in cardiovascular homeostasis and how deranged endothelial-related signaling pathways contribute to the development of HFPEF. We also review the novel therapies in various stages of research and development that target different components of this signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.