Observational studyNeuroradiology2016
CT angiography and CT perfusion improve prediction of infarct volume in patients with anterior circulation stroke.
Observational study in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Endovascular Therapy for Acute Basilar Artery Occlusion: Prognosis Prediction Value from Clinical to Imaging Variables.Revista de neurologia · 2025Article
- Outcome prediction value of critical area perfusion score for acute basilar artery occlusion.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Estimation of ischemic core in acute ischemic stroke with CT angiography and non-contrast CT: Attenuation changes in ASPECTS regions vs. automated ASPECTS scoring.Frontiers in neuroscience · 2022Article
- ColorViz, a New and Rapid Tool for Assessing Collateral Circulation during Stroke.Brain sciences · 2020Article
- Clinical Factors Associated with Deep Vein Thrombosis in Rehabilitation Patients Suspected of Thromboembolism after Cerebral Infarction.Brain & NeuroRehabilitation · 2020Article
- Incremental Value of Computed Tomography Perfusion for Final Infarct Prediction in Acute Ischemic Cerebellar Stroke.Journal of the American Heart Association · 2019Article
- Cognitive Decline in Asymptomatic Middle Cerebral Artery Stenosis Patients with Moderate and Poor Collaterals: A 2-Year Follow-Up Study.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- CT perfusion hypervolemia: brain ischemia or stroke mimic?Neuroradiology · 2019Article
- The Effect of Intensive Statin Therapy on Symptomatic Intracranial Arterial Stenosis.Iranian journal of public health · 2018Article
- Improving Regional Stroke Systems of Care.Current atherosclerosis reports · 2017Review
- Temporal profile of body temperature in acute ischemic stroke: relation to infarct size and outcome.BMC neurology · 2016Article
- Determinants of leptomeningeal collateral flow in stroke patients with a middle cerebral artery occlusion.Neuroradiology · 2016Article
- Computed tomography perfusion stroke mimics on RAPID commercial software: A case-based review.Brain circulationReview
Corrections and comments
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Authors and funding
32 authors at 11 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe investigated whether baseline CT angiography (CTA) and CT perfusion (CTP) in acute ischemic stroke could improve prediction of infarct presence and infarct volume on follow-up imaging.
methodsWe analyzed 906 patients with suspected anterior circulation stroke from the prospective multicenter Dutch acute stroke study (DUST). All patients underwent baseline non-contrast CT, CTA, and CTP and follow-up non-contrast CT/MRI after 3 days. Multivariable regression models were developed including patient characteristics and non-contrast CT, and subsequently, CTA and CTP measures were added. The increase in area under the curve (AUC) and R (2) was assessed to determine the additional value of CTA and CTP.
resultsAt follow-up, 612 patients (67.5%) had a detectable infarct on CT/MRI; median infarct volume was 14.8 mL (interquartile range (IQR) 2.8-69.6). Regarding infarct presence, the AUC of 0.82 (95% confidence interval (CI) 0.79-0.85) for patient characteristics and non-contrast CT was improved with addition of CTA measures (AUC 0.85 (95% CI 0.82-0.87); p < 0.001) and was even higher after addition of CTP measures (AUC 0.89 (95% CI 0.87-0.91); p < 0.001) and combined CTA/CTP measures (AUC 0.89 (95% CI 0.87-0.91); p < 0.001). For infarct volume, adding combined CTA/CTP measures (R (2) = 0.58) was superior to patient characteristics and non-contrast CT alone (R (2) = 0.44) and to addition of CTA alone (R (2) = 0.55) or CTP alone (R (2) = 0.54; all p < 0.001).
conclusionIn the acute stage, CTA and CTP have additional value over patient characteristics and non-contrast CT for predicting infarct presence and infarct volume on follow-up imaging. These findings could be applied for patient selection in future trials on ischemic stroke treatment.
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