Evidence map›Paper›PMID 26767377›Full record

Trial reportAge (Dordrecht, Netherlands)2016

Heterogeneity in resistance training-induced muscle strength and mass responses in men and women of different ages.

Juha P Ahtiainen, Simon Walker, Heikki Peltonen, Jarkko Holviala, Elina Sillanpää, Laura Karavirta, Janne Sallinen, Jussi Mikkola, Heli Valkeinen, Antti Mero and 2 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Age (Dordrecht, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 108 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05772910 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Viability of an Educational Program for Lifestyle Changes and an Algorithm for the Derivation of Exercise Programs in Older People at Risk of Dependency at Primary Care.

TypeinterventionalSponsorUniversity of CadizRan2024 to 2026Enrolled110ConditionsFrailty, Disability Physical, Old Age, AtrophyArmsEDUcation, EXERcise, EDU-EXER, CONtrol
NCT07721766 narecruitingnot on this mapstarted 2026, after this paper: background citation

HyperLa: Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training: A Multi-centre Study by the HyperLa Study Group

TypeinterventionalSponsorTechnical University of MunichRan2026 to 2026Enrolled120ConditionsHealthy Volunteers, Muscle Hypertrophy, Glycolysis, Moderately TrainendArmsHypertrophy-focused Resistance Training
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Adjunctive Ashwagandha (Nutrients · 2026
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  15. Variability in resistance training trajectories of breast cancer patients undergoing therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Juha P AhtiainenDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland. juha.ahtiainen@jyu.fi.
Simon WalkerDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
Heikki PeltonenDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
Jarkko HolvialaDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
Elina SillanpääGerontology Research Center, Department of Health Sciences, University of Jyväskylä, Jyvaskyla, Finland.
Laura KaravirtaDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
Janne SallinenDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
Jussi MikkolaPhysiology, Research Institute for Olympic Sports, Jyväskylä, Finland.
Heli ValkeinenDepartment of Welfare, National Institute for Health and Welfare (THL), Helsinki, Finland.
Antti MeroDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
Juha J HulmiDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
Keijo HäkkinenDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity recommendations for public health include typically muscle-strengthening activities for a minimum of 2 days a week. The range of inter-individual variation in responses to resistance training (RT) aiming to improve health and well-being requires to be investigated. The purpose of this study was to quantify high and low responders for RT-induced changes in muscle size and strength and to examine possible effects of age and sex on these responses. Previously collected data of untrained healthy men and women (age 19 to 78 years, n = 287 with 72 controls) were pooled for the present study. Muscle size and strength changed during RT are 4.8 ± 6.1 % (range from -11 to 30 %) and 21.1 ± 11.5 % (range from -8 to 60 %) compared to pre-RT, respectively. Age and sex did not affect to the RT responses. Fourteen percent and 12 % of the subjects were defined as high responders (>1 standard deviation (SD) from the group mean) for the RT-induced changes in muscle size and strength, respectively. When taking into account the results of non-training controls (upper 95 % CI), 29 and 7 % of the subjects were defined as low responders for the RT-induced changes in muscle size and strength, respectively. The muscle size and strength responses varied extensively between the subjects regardless of subject's age and sex. Whether these changes are associated with, e.g., functional capacity and metabolic health improvements due to RT requires further studies.

Indexed as

AdultAgedAgingFemaleFollow-Up StudiesHealthy VolunteersHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthResistance TrainingRetrospective StudiesTime FactorsYoung AdultAgingIndividual variationMuscle hypertrophyResponders

Identifiers

PMID26767377
PMCPMC5005877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.