Evidence map›Paper›PMID 26767175›Full record

ArticlePublic health action2015

Setting priorities for a research agenda to combat drug-resistant tuberculosis in children.

B Velayutham, D Nair, S Ramalingam, C M Perez-Velez, M C Becerra, S Swaminathan

Abstract read
In one paragraph

Article in Public health action, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2019
    Guideline
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

B VelayuthamNational Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Chennai, India.
D NairNational Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Chennai, India.
S RamalingamNational Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Chennai, India.
C M Perez-VelezBanner Good Samaritan Medical Center, The University of Arizona College of Medicine, Phoenix, Arizona, USA.
M C BecerraDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
S SwaminathanNational Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

settingNumerous knowledge gaps hamper the prevention and treatment of childhood drug-resistant tuberculosis (TB). Identifying research priorities is vital to inform and develop strategies to address this neglected problem.

objectiveTo systematically identify and rank research priorities in childhood drug-resistant TB.

designAdapting the Child Health and Nutrition Research Initiative (CHNRI) methodology, we compiled 53 research questions in four research areas, then classified the questions into three research types. We invited experts in childhood drug-resistant TB to score these questions through an online survey.

resultsA total of 81 respondents participated in the survey. The top-ranked research question was to identify the best combination of existing diagnostic tools for early diagnosis. Highly ranked treatment-related questions centred on the reasons for and interventions to improve treatment outcomes, adverse effects of drugs and optimal treatment duration. The prevalence of drug-resistant TB was the highest-ranked question in the epidemiology area. The development type questions that ranked highest focused on interventions for optimal diagnosis, treatment and modalities for treatment delivery.

conclusionThis is the first effort to identify and rank research priorities for childhood drug-resistant TB. The result is a resource to guide research to improve prevention and treatment of drug-resistant TB in children.

Indexed as

adolescentchildhoodpaediatricSentinel Project

Identifiers

PMID26767175
PMCPMC4682613

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.