ArticleAnnals of occupational and environmental medicine2016
Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1(st) Korean National Environmental Health Survey.
Article in Annals of occupational and environmental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity: a systematic review and meta-analysis.BMJ open · 2020Pooled it
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- A systematic review of human biomonitoring studies of 3-phenoxybenzoic acid, a urinary biomarker pyrethroid insecticide exposure, 1997 to 2019.Hygiene and environmental health advances · 2022Article
- Resistance to Cypermethrin Is Widespread in Cattle Ticks (Pathogens (Basel, Switzerland) · 2022Article
- The effects of chemical mixtures on lipid profiles in the Korean adult population: threshold and molecular mechanisms for dyslipidemia involved.Environmental science and pollution research international · 2022Article
- Mixtures modeling identifies heavy metals and pyrethroid insecticide metabolites associated with obesity.Environmental science and pollution research international · 2022Article
- Household insecticide use and urinary 3-phenoxybenzoic acid levels in an elder population: a repeated measures data.Journal of exposure science & environmental epidemiology · 2021Article
- The concomitant effects of self-limiting insect releases and behavioural interference on patterns of coexistence and exclusion of competing mosquitoes.Proceedings. Biological sciences · 2021Article
- Predictors of Urinary Pyrethroid and Organophosphate Compound Concentrations among Healthy Pregnant Women in New York.International journal of environmental research and public health · 2020Article
- Chronic cypermethrin exposure alters mouse embryonic stem cell growth kinetics, induces Phase II detoxification response and affects pluripotency and differentiation gene expression.European journal of histochemistry : EJH · 2020Article
- Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study.Environmental health : a global access science source · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccording to US-EPA report, the use of pyrethrins and pyrethroids has increased during the past decade, and their area of use included not only in agricultural settings, but in commerce, and individual household. It is known that urinary 3-PBA, major metabolite of pyrethroid, have some associations with health effect in nervous and endocrine system, however, there's no known evidence that urinary 3-PBA have associations with obesity.
methodWe used data of 3671 participants aged above 19 from the Korean National Environmental Health Survey in 2009-2011. In our analysis, multivariate piece-wise regression and logistic regression analysis were used to investigate the association between urinary 3-PBA (3-Phenoxybenzoic Acid) and BMI.
resultLog-transformed level of urinary 3-PBA had significantly positive association with BMI at the low-level range of exposure (p < 0.0001), and opposite associations were observed at the high level exposure (p = 0.04) after adjusting covariates. In piece-wise regression analysis, the flexion point that changes direction of the associations was at around 4 ug/g creatinine of urinary 3-PBA. As quintiles based on concentration of urinary 3-PBA increased to Q4, the ORs for prevalence of overweight (BMI ≥ 23 kg/m(2)) were increased, and the OR of Q5 was lower than that of Q4 (OR = 1.810 for Q4; OR = 1.483 for Q5). In the analysis using obesity (BMI ≥ 25 kg/m(2)) as outcome variable, significant associations were observed between obesity and quintiles of 3-PBA, however, there were no differences between the OR of Q5 and that of Q4 (OR = 1.659 for Q4; OR = 1.666 for Q5).
conclusionOur analysis suggested that low-level of pyrethroid exposure has positive association with BMI, however, there is an inverse relationship above the urinary 3-PBA level at 4 ug/g creatinine.
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