ArticleThoracic cancer2014
Diagnostic value of serum glutathione peroxidase 3 levels in patients with lung cancer.
Article in Thoracic cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Advances in the role of GPX3 in ovarian cancer (Review).International journal of oncology · 2024Article
- Systematic identification of key extracellular proteins as the potential biomarkers in lupus nephritis.Frontiers in immunology · 2022Article
- Potential relationship between the selenoproteome and cancer.Molecular and clinical oncology · 2020Article
- Glutathione Peroxidase 3 as a Biomarker of Recurrence after Lung Cancer Surgery.Journal of clinical medicine · 2020Article
- Review
- Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field.Oxidative medicine and cellular longevity · 2019Review
- Integrative analysis for the discovery of lung cancer serological markers and validation by MRM-MS.PloS one · 2017Article
- Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells.Molecules and cells · 2016Article
- MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC.Scientific reports · 2016Article
- Minichromosome maintenance complex component 7 has an important role in the invasion of papillary urothelial neoplasia.Oncology letters · 2015Article
- Abnormal expression of NSF, α-SNAP and SNAP23 in pulmonary arterial hypertension in rats treated with monocrotaline.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe selected glutathione peroxidase 3 (GPx3) as a specific candidate that is down regulated in patients with lung cancer. In this study, we examined the diagnostic value of serum GPx3, which is an extracellular protein and readily detectable in blood.
methodsWe collected serum samples from 342 patients with lung cancer and 126 controls (normal healthy people and patients with benign diseases or other malignancies). We measured serum GPx3 levels using the enzyme-linked immunosorbent assay.
resultsMean serum GPx3 levels were significantly lower in the patient group compared with the control group (10.1 ± 5.0 μg/mL vs. 13.0 ± 5.8 μg/mL, P < 0.001). In addition, mean serum GPx3 levels tended to be lower in the patients without metastasis compared with those with metastasis (9.6 ± 4.5 μg/mL vs. 10.7 ± 5.7 μg/mL, P = 0.051). Furthermore, mean serum GPx3 levels had a significant difference according to initial treatments (P < 0.001). In other words, mean serum GPx3 levels were significantly lower in the surgery group (8.2 ± 4.1 μg/mL) compared with the concurrent chemoradiotherapy (11.5 ± 4.6 μg/mL, P < 0.001), chemotherapy (10.7 ± 5.6 μg/mL, P < 0.001), and supportive care groups (10.9 ± 4.8 μg/mL, P = 0.002).
conclusionOur results showed that serum GPx3 levels were significantly lower in the patients who underwent surgery, which indicates that the serum may have diagnostic value in patients at an operable stage of lung cancer, rather than those at a locally advanced or metastatic stage.
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