ArticleInternational journal of nanomedicine2016
Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites.
Article in International journal of nanomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 78 citations in OpenAlex.
- AuAg-Carbon-Based Quantum Dot Nanocomposites to Reduce Andrographolide's Hydrophobicity and Drug Internalization Tracking in PC-3 Cells.Nanomaterials (Basel, Switzerland) · 2026Article
- A Review on Pulsed Laser-Based Synthesis of Carbon and Graphene Quantum Dots in Liquids: From Fundamentals, Chemistry to Bio Applications and Beyond.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025Review
- Concentration-dependent disturbances of digestive functions in house cricket (Insecta: Orthoptera) exposed to GO-AgNP composite.Scientific reports · 2025Article
- Metal grafted graphene-based nanomaterials towards cancer theranostic efficacy.Exploration of targeted anti-tumor therapy · 2025Review
- Quantum Dots in Cancer Theranostics: A Thorough Review of Recent Advancements in Bioimaging, Tracking, and Therapy Across Various Cancer Types.Current pharmaceutical biotechnology · 2025Review
- Graphene Quantum Dots from Natural Carbon Sources for Drug and Gene Delivery in Cancer Treatment.International journal of molecular sciences · 2024Review
- Review
- Quantum Dots as a Potential Multifunctional Material for the Enhancement of Clinical Diagnosis Strategies and Cancer Treatments.Nanomaterials (Basel, Switzerland) · 2024Review
- Recent Breakthroughs in Using Quantum Dots for Cancer Imaging and Drug Delivery Purposes.Nanomaterials (Basel, Switzerland) · 2023Review
- Lights and Dots toward Therapy-Carbon-Based Quantum Dots as New Agents for Photodynamic Therapy.Pharmaceutics · 2023Review
- Article
- Review
- Nanomaterials in Animal Husbandry: Research and Prospects.Frontiers in genetics · 2022Review
- Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells.Molecules (Basel, Switzerland) · 2021Article
- Graphene oxide and its nanocomposites with EDTA or chitosan induce apoptosis in MCF-7 human breast cancer.RSC advances · 2021Article
- Synthesis of Graphene Quantum Dots Decorated With Se, Eu and Ag As Photosensitizer and Study of Their Potential to Use in Photodynamic Therapy.Journal of fluorescence · 2021Article
- Improved antimicrobial properties of methylene blue attached to silver nanoparticles.Photodiagnosis and photodynamic therapy · 2020Article
- Graphene quantum dots in photodynamic therapy.Nanoscale advances · 2020Article
- Functionalization and optimization-strategy of graphene oxide-based nanomaterials for gene and drug delivery.American journal of translational research · 2020Review
- Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The combination of chemotherapy and photodynamic therapy has emerged as a promising strategy for cancer therapy due to its synergistic effects. In this work, PEGylated silver nanoparticles decorated with graphene quantum dots (Ag-GQDs) were tested as a platform to deliver a chemotherapy drug and a photosensitizer, simultaneously, in chemo-photodynamic therapy against HeLa and DU145 cancer cells in vitro. Ag-GQDs have displayed high efficiency in delivering doxorubicin as a model chemotherapy drug to both cancer cells. The Ag-GQDs exhibited a strong antitumor activity by inducing apoptosis in cancer cells without affecting the viability of normal cells. Moreover, the Ag-GQDs exhibited a cytotoxic effect due to the generation of the reactive singlet oxygen upon 425 nm irradiation, indicating their applicability in photodynamic therapy. In comparison with chemo or photodynamic treatment alone, the combined treatment of Ag-GQDs conjugated with doxorubicin under irradiation with a 425 nm lamp significantly increased the death in DU145 and HeLa. This study suggests Ag-GQDs as a multifunctional and efficient therapeutic system for chemo-photodynamic modalities in cancer therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.