ArticlePloS one2016
Serotonin Improves High Fat Diet Induced Obesity in Mice.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 110 citations in OpenAlex.
- Inulin supplementation modulates gut microbiota derived metabolites related to brain function in children with obesity.Scientific reports · 2025Trial
- Neural mechanisms linking Western diet consumption and cognitive impairment: a role for the vagus nerve.Clinical science (London, England : 1979) · 2026Review
- Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring.Journal of neurochemistry · 2025Review
- Review
- Effects of Different Photoperiods on Peripheral 5-Hydroxytryptamine Metabolism, Breast Muscle Glucose Metabolism, and Myopathies in Broilers.Metabolites · 2024Article
- Improvement of insulin sensitivity by dietary fiber consumption during late pregnant sows is associated with gut microbiota regulation of tryptophan metabolism.Animal microbiome · 2024Article
- Novel therapeutic strategy for obesity through the gut microbiota-brain axis: A review article.Caspian journal of internal medicine · 2024Review
- Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review.Cell & bioscience · 2023Review
- Metabolomic Study of Aging inMetabolites · 2023Article
- Metabolic and Molecular Response to High-Fat Diet Differs between Rats with Constitutionally High and Low Serotonin Tone.International journal of molecular sciences · 2023Article
- Buspirone Induces Weight Loss and Normalization of Blood Pressure via the Stimulation of PPARPPAR research · 2023Article
- Maternal Gestational Diabetes Influences DNA Methylation in the Serotonin System in the Human Placenta.Life (Basel, Switzerland) · 2022Article
- Melanocortin Signaling Connecting Systemic Metabolism With Mood Disorders.Biological psychiatry · 2022Review
- Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.Nature metabolism · 2021Article
- Epigenetic Alterations Related to Gestational Diabetes Mellitus.International journal of molecular sciences · 2021Review
- Epigenetic Changes in Gestational Diabetes Mellitus.International journal of molecular sciences · 2021Review
- The Role of the Gut Microbiota in the Gut-Brain Axis in Obesity: Mechanisms and Future Implications.International journal of molecular sciences · 2021Review
- Investigating the complex interplay between genotype and high-fat-diet feeding in the lactating mammary gland using theAmerican journal of physiology. Endocrinology and metabolism · 2021Article
- Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD.Life (Basel, Switzerland) · 2020Article
- Comparative Transcriptome Analyses ofFrontiers in microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.