ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2016
Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Maternal Hypertensive Disorders of Pregnancy and the Risk of Childhood Asthma.Annals of the American Thoracic Society · 2023Article
- A comparison of case definitions for infant atopic dermatitis in a multicenter prospective cohort study.Health science reports · 2021Article
- Respiratory health, allergies, and the farm environment: design, methods and enrollment in the observational Wisconsin Infant Study Cohort (WISC): a research proposal.BMC research notes · 2019Article
- Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.Nature neuroscience · 2019Article
- RSV-hRV co-infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis.Journal of medical virology · 2018Article
- Prediction and prevention of allergy and asthma in EAACI journals (2016).Clinical and translational allergy · 2017Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInfants hospitalized for bronchiolitis (i.e. severe bronchiolitis) are at increased risk of childhood asthma. There are many known risk factors for severe bronchiolitis, including cardiac and pulmonary diseases. Less is known about the association between atopic diseases and risk of severe bronchiolitis. We sought to further examine risk factors for severe bronchiolitis, focusing on atopic dermatitis (AD).
methodsWe conducted a nested cohort study within the Massachusetts General Hospital Obstetric Maternal Study (MOMS), a prospective cohort of pregnant women enrolled during 1998-2006. Children of mothers enrolled in MOMS were included in the analysis if they received care within our health system (n = 5407). Potential risk factors for bronchiolitis and hospitalization data were extracted from the children's electronic health records; we also examined pregnancy and perinatal risk factors collected from the underlying MOMS data.
resultsDuring the first year of life, 125 infants (2.3%) had severe bronchiolitis. Eighteen of these patients had AD; 11 (61%) were diagnosed with AD prior to bronchiolitis hospitalization. In unadjusted analyses, AD was associated with severe bronchiolitis (χ(2) 14.6; p < 0.001). In multivariable analyses adjusting for nine known risk factors for severe bronchiolitis, including demographics, birth season, disposition at birth, cardiac disease, maternal parity, and delivery mode, AD was associated with increased odds of severe bronchiolitis (odds ratio 2.72, 95% confidence interval 1.60-4.63).
conclusionsAtopic dermatitis is significantly associated with severe bronchiolitis in infancy. The mechanism of the AD-bronchiolitis association is unclear and merits further study; this research may shed light on the pathogenesis of asthma.
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