Trial reportPsychoneuroendocrinology2016
Acute stress alters autonomic modulation during sleep in women approaching menopause.
Trial report in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- The Effects of Presleep Slow Breathing and Music Listening on Polysomnographic Sleep Measures - a pilot trial.Scientific reports · 2020Trial
- Reducing bedtime physiological arousal levels using immersive audio-visual respiratory bio-feedback: a pilot study in women with insomnia symptoms.Journal of behavioral medicine · 2019Trial
- Trait-like individual signatures dominate sleep EEG over insomnia-specific features.Scientific reports · 2026Article
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- The influence of menopausal status on sleep quality in different populations - a narrative review.Przeglad menopauzalny = Menopause review · 2025Review
- Effect of Baduanjin Qigong on Sleep Quality and Hyperarousal State in Adults With Chronic Insomnia: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- [Exploring the therapeutic mechanism ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Core body temperature changes before sleep are associated with nocturnal heart rate variability.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Stress, hypothalamic pituitary adrenal axis activity and autonomic nervous system function in adolescents with insomnia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Physiological responses to acute psychosocial stress in women with menopausal insomnia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2021Article
- Genetic versus stress and mood determinants of sleep in the Amish.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- Stress, sleep, and autonomic function in healthy adolescent girls and boys: Findings from the NCANDA study.Sleep health · 2021Article
- When sleep goes virtual: the potential of using virtual reality at bedtime to facilitate sleep.Sleep · 2020Article
- Effects of night-time on-call work on heart rate variability before bed and sleep quality in visiting nurses.International archives of occupational and environmental health · 2018Article
- Factors associated with poor sleep during menopause: results from the Midlife Women's Health Study.Sleep medicine · 2018Article
- Sex- and Age-Dependent Differences in Autonomic Nervous System Functioning in Adolescents.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2018Article
- Sleep problems during the menopausal transition: prevalence, impact, and management challenges.Nature and science of sleep · 2018Review
- Sleep, Health and Wellness at Work: A Scoping Review.International journal of environmental research and public health · 2017Article
- Menstrual cycle-related variation in autonomic nervous system functioning in women in the early menopausal transition with and without insomnia disorder.Psychoneuroendocrinology · 2017Article
- A virtual reality-based mind-body approach to downregulate psychophysiological arousal in adolescent insomnia.Digital healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Hot flashes, hormones, and psychosocial factors contribute to insomnia risk in the context of the menopausal transition. Stress is a well-recognized factor implicated in the pathophysiology of insomnia; however the impact of stress on sleep and sleep-related processes in perimenopausal women remains largely unknown. We investigated the effect of an acute experimental stress (impending Trier Social Stress Task in the morning) on pre-sleep measures of cortisol and autonomic arousal in perimenopausal women with and without insomnia that developed in the context of the menopausal transition. In addition, we assessed the macro- and micro-structure of sleep and autonomic functioning during sleep. Following adaptation to the laboratory, twenty two women with (age: 50.4 ± 3.2 years) and eighteen women without (age: 48.5 ± 2.3 years) insomnia had two randomized in-lab overnight recordings: baseline and stress nights. Anticipation of the task resulted in higher pre-sleep salivary cortisol levels and perceived tension, faster heart rate and lower vagal activity, based on heart rate variability measures, in both groups of women. The effect of the stress manipulation on the autonomic nervous system extended into the first 4 h of the night in both groups. However, vagal tone recovered 4-6 h into the stress night in controls but not in the insomnia group. Sleep macrostructure was largely unaltered by the stress, apart from a delayed latency to REM sleep in both groups. Quantitative analysis of non-rapid eye movement sleep microstructure revealed greater electroencephalographic (EEG) power in the beta1 range (15-≤23 Hz), reflecting greater EEG arousal during sleep, on the stress night compared to baseline, in the insomnia group. Hot flash frequency remained similar on both nights for both groups. These results show that pre-sleep stress impacts autonomic nervous system functioning before and during sleep in perimenopausal women with and without insomnia. Findings also indicate that women with insomnia had increased EEG arousal and lacked recovery in vagal activity across the stress night suggesting a greater sensitivity to stress in this group.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.