ArticleAIDS (London, England)2016
Adult life expectancy trends in the era of antiretroviral treatment in rural Uganda (1991-2012).
Article in AIDS (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Association Between Altered Lung MicroBiome and HIV-associated Chronic Obstructive Pulmonary Disease in a Ugandan Cohort
Airway Microbiome and Th17-mediated Inflammation in COPD Among HIV-infected Individuals in a Rural Ugandan Cohort
Who cites it
26 citing papers in PubMed.
- Effect of a Peer Support Intervention for Oral Pre-Exposure Prophylaxis Uptake and Adherence Among Adolescent Girls and Young Women at Risk of HIV Acquisition in Kampala, Uganda: A Randomized Controlled Trial.Journal of the International AIDS Society · 2026Trial
- High prevalence of non-communicable diseases and associated risk factors amongst adults living with HIV in Cambodia.PloS one · 2017Trial
- Estimation of cause-specific mortality in Rakai, Uganda, using verbal autopsy 1999-2019.Global health action · 2024Article
- Characteristics and phenotypes of a COPD cohort from referral hospital clinics in Uganda.BMJ open respiratory research · 2024Article
- Mode of HIV exposure and excess burden of neurocognitive impairment in people living with HIV: a protocol for systematic review and meta-analysis of controlled studies.Systematic reviews · 2023Article
- Associations between treatment burden, self-reported treatment qualities, antiretroviral therapy obtainment, and health-related quality of life among Ugandan PLWH.Cost effectiveness and resource allocation : C/E · 2023Article
- A Multilevel Integrated Intervention to Reduce the Impact of HIV Stigma on HIV Treatment Outcomes Among Adolescents Living With HIV in Uganda: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2022Article
- The contribution of social norms and religious practices towards low death registration in 3 HDSS sites of Uganda.BMC health services research · 2022Article
- HIV, tuberculosis, diabetes mellitus and hypertension admissions and premature mortality among adults in Uganda from 2011 to 2019: is the tide turning?Tropical medicine and health · 2022Article
- Observational
- Article
- Predictors of lost to follow-up in a "test and treat" programme among adult women with high-risk sexual behavior in Kampala, Uganda.BMC public health · 2020Article
- Population-level adult mortality following the expansion of antiretroviral therapy in Rakai, Uganda.Population studies · 2020Article
- HIV treatment in Guinea-Bissau: room for improvement and time for new treatment options.AIDS research and therapy · 2020Review
- Experiences and perceptions of youth living with HIV in Western Uganda on school attendance: barriers and facilitators.BMC public health · 2020Article
- Variation in KSHV prevalence between geographically proximate locations in Uganda.Infectious agents and cancer · 2020Article
- Profile of elderly patients receiving antiretroviral therapy at Newlands Clinic in 2020: A cross-sectional study.Southern African journal of HIV medicine · 2020Article
- Achieving the fourth 90: healthy aging for people living with HIV.AIDS (London, England) · 2018Article
- Expert consensus statement on the science of HIV in the context of criminal law.Journal of the International AIDS Society · 2018Article
- Kaposi Sarcoma-Associated Herpesvirus in a Rural Ugandan Cohort, 1992-2008.The Journal of infectious diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveTo estimate the impact of antiretroviral therapy (ART) on population-wide adult life expectancy. STUDY
designA population-based open cohort study with repeated HIV status measurements and registration of vital events in Southwestern Uganda (1991-2012).
methodsNonparametric survival analysis techniques are used for estimating trends in the adult life expectancy of the general population (aged 15 and above), the adult life expectancy by HIV status, and the adult life expectancy deficit. The life expectancy deficit is estimated as the difference between overall life expectancy and life expectancy of the HIV-negative population. All estimates are disaggregated by sex.
resultsBetween 1991-1993 and 2009-2012, population-wide adult life expectancy increased from 39.3 [95% confidence interval (CI): 35.9-42.8] to 56.1 years (95% CI: 54.0-58.5) in women, and from 38.6 (95% CI: 35.4-42.1) to 51.4 years (95% CI: 49.2-53.7) in men. Most of the adult life expectancy gains coincide with the introduction of ART in 2004; as evidenced by an increase in the adult life expectancy of people living with HIV between 2000-2002 and 2009-2012 of 22.9 and 20.0 years for women and men, respectively. Over the whole period of observation, the adult life expectancy deficit associated with HIV decreased from 16.1 (95% CI: 12.7-19.8) to 6.0 years (95% CI: 4.1-7.8) among women, and from 16.0 (95% CI: 12.1-19.9) to 2.8 years (95% CI: 1.2-4.6) among men.
conclusionPopulation-wide life expectancy increased substantially, largely driven by reductions in HIV-related mortality. Women have gained more adult life years than men since the introduction of ART, but the burden of HIV in terms of the life years lost is still larger for women than it is for men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.