ArticlePloS one2016
RNA-Seq Reveals OTA-Related Gene Transcriptional Changes in Aspergillus carbonarius.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of stilbenoids on growth, mycotoxin production and transcriptomic profiles of Aspergillus carbonarius causing postharvest black spot disease.World journal of microbiology & biotechnology · 2026Article
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- Transcriptome analysis of Ochratoxin a (OTA) producingMycology · 2025Article
- Article
- Unlocking the Transcriptional Reprogramming Repertoire between Variety-Dependent Responses of Grapevine Berries to Infection byPlants (Basel, Switzerland) · 2024Article
- Current Approaches for Advancement in Understanding the Molecular Mechanisms of Mycotoxin Biosynthesis.International journal of molecular sciences · 2021Review
- Review
- Functional Role ofToxins · 2021Article
- Carbon Catabolite Repression GeneToxins · 2020Article
- A Consensus Ochratoxin A Biosynthetic Pathway: Insights from the Genome Sequence of Aspergillus ochraceus and a Comparative Genomic Analysis.Applied and environmental microbiology · 2018Article
- Article
- Genomic diversity in ochratoxigenic and non ochratoxigenic strains of Aspergillus carbonarius.Scientific reports · 2018Article
- Article
- Sequencing and functional annotation of the whole genome of the filamentous fungus Aspergillus westerdijkiae.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ochratoxin A (OTA) is a mycotoxin harmful for animals and humans. Aspergillus carbonarius is the main responsible for OTA contamination of grapes and derived products. Gene transcriptional profiling of 4 A. carbonarius strains was carried out by RNA-Seq analysis to study transcriptome changes associated with OTA production. By comparing OTA inducing (OTAI) vs. non-inducing (OTAN) cultural conditions, a total of 3,705 differentially expressed genes (DEGs) (fold change > |2| and FDR ≤ 0.05) were identified. Several genes involved in primary metabolic processes, with particular regard to carbohydrate and amino acid metabolisms, secondary metabolic processes, transport, response to stress and sporulation were up-regulated by OTAI conditions at all the analysed sampling times (4, 6 and 8 DAI) or starting from 6 DAI. Highly up-regulated DEGs encoding enzymes involved in biosynthesis of secondary metabolites, oxidoreductases, transporters and transcription factors were examined for their potential involvement in OTA biosynthesis and related metabolic pathways. Differential expression of genes encoding polyketide synthases (pks), non-ribosomal peptide synthetases (nrps) and chloroperoxidase (cpo) was validated by RT-qPCR. Among clusters of co-regulated genes involved in SM biosynthesis, one putative OTA-gene cluster, including both pks and nrps genes, was detected in the A. carbonarius genome.
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