Evidence map›Paper›PMID 26765347›Full record

SynthesisJournal of the International AIDS Society2016

TB as a cause of hospitalization and in-hospital mortality among people living with HIV worldwide: a systematic review and meta-analysis.

Nathan Ford, Alberto Matteelli, Zara Shubber, Sabine Hermans, Graeme Meintjes, Beatriz Grinsztejn, Greer Waldrop, Katharina Kranzer, Meg Doherty, Haileyesus Getahun

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the International AIDS Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 12 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 12 syntheses or guidelines pooled it, 172 citations in OpenAlex.

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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 8 countries.

Nathan FordDepartment of HIV, World Health Organization, Geneva, Switzerland; fordn@who.int.
Alberto MatteelliGlobal TB Programme, World Health Organization, Geneva, Switzerland.
Zara ShubberDepartment of Infectious Disease Epidemiology, Imperial College London, London, UK.
Sabine HermansDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Graeme MeintjesClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Beatriz GrinsztejnInstituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Ministry of Health, Rio de Janeiro, Brazil.
Greer WaldropUniversity of Maryland school of Medicine, Baltimore, MD, USA.
Katharina KranzerDepartment of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Meg DohertyDepartment of HIV, World Health Organization, Geneva, Switzerland.
Haileyesus GetahunGlobal TB Programme, World Health Organization, Geneva, Switzerland.
World Health Organization · CHImperial College London · GBLondon School of Hygiene & Tropical Medicine · GBMinistério da Saúde · BRUniversity of Cape Town · ZAUniversity of Maryland, Baltimore · USWellcome Centre for Infectious Diseases Research in Africa · ZA

Funding

The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials)UM1AI069476 · NIAID · FUNDACAO OSWALDO CRUZ · PI BEATRIZ GRINSZTEJN · 2012 to 2026
$26.3M
NIAID NIH HHS UM1 AI069476
6 · The paper itself

Abstract

introductionDespite significant progress in improving access to antiretroviral therapy over the past decade, substantial numbers of people living with HIV (PLHIV) in all regions continue to experience severe illness and require hospitalization. We undertook a global review assessing the proportion of hospitalizations and in-hospital deaths because of tuberculosis (TB) in PLHIV.

methodsSeven databases were searched to identify studies reporting causes of hospitalizations among PLHIV from 1 January 2007 to 31 January 2015 irrespective of age, geographical region or language. The proportion of hospitalizations and in-hospital mortality attributable to TB was estimated using random effects meta-analysis.

resultsFrom an initial screen of 9049 records, 66 studies were identified, providing data on 35,845 adults and 2792 children across 42 countries. Overall, 17.7% (95% CI 16.0 to 20.2%) of all adult hospitalizations were because of TB, making it the leading cause of hospitalization overall; the proportion of adult hospitalizations because of TB exceeded 10% in all regions except the European region. Of all paediatric hospitalizations, 10.8% (95% CI 7.6 to 13.9%) were because of TB. There was insufficient data among children for analysis by region. In-hospital mortality attributable to TB was 24.9% (95% CI 19.0 to 30.8%) among adults and 30.1% (95% CI 11.2 to 48.9%) among children. DISCUSSION: TB remains a leading cause of hospitalization and in-hospital death among adults and children living with HIV worldwide.

Indexed as

Hospital MortalityAdultChildHIV InfectionsHospitalizationHumansMaleTuberculosisHIV/AIDShospitalizationmorbiditymortalitytuberculosis

Identifiers

PMID26765347
PMCPMC4712323
OpenAlexW2237953232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.