ArticleGenes and immunity2016
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.
Article in Genes and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Genome-wide meta-analysis in lichen sclerosus identifies 14 genomic risk loci.The British journal of dermatology · 2026Article
- TAGAP restrains myeloid and T cell activation in inflammatory bowel disease.Frontiers in immunology · 2025Article
- TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development.Clinical and experimental immunology · 2023Article
- A comprehensive review on the impact of calcium and vitamin D insufficiency and allied metabolic disorders in females.Food science & nutrition · 2023Review
- 1,25-Dihydroxyvitamin D3 suppresses CD4Immunology · 2022Article
- The gut microbiome molecular mimicry piece in the multiple sclerosis puzzle.Frontiers in immunology · 2022Review
- Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications.Brain communications · 2022Review
- Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers.Frontiers in immunology · 2022Article
- Association of miR-499 Polymorphism and Its Regulatory Networks with Hashimoto Thyroiditis Susceptibility: A Population-Based Case-Control Study.International journal of molecular sciences · 2021Article
- The IL-2 - IL-2 receptor pathway: Key to understanding multiple sclerosis.Journal of translational autoimmunity · 2021Review
- Article
- Control of T Cell Metabolism by Cytokines and Hormones.Frontiers in immunology · 2021Review
- The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses.Biology · 2020Review
- Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis.British journal of pharmacology · 2020Review
- Analysis of Single Nucleotide Polymorphisms inReports of biochemistry & molecular biology · 2020Article
- Multiple Sclerosis: Lipids, Lymphocytes, and Vitamin D.Immunometabolism · 2020Article
- RNAi-mediated knockdown of VDR surprisingly suppresses cell growth in Jurkat T and U87-MG cells.Heliyon · 2019Article
- Replication study of GWAS risk loci in Greek multiple sclerosis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond.Frontiers in immunology · 2019Review
- Emerging small-molecule treatments for multiple sclerosis: focus on B cells.F1000Research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system that develops in genetically susceptible individuals. The majority of the MS-associated gene variants are located in genetic regions with importance for T-cell differentiation. Vitamin D is a potent immunomodulator, and vitamin D deficiency has been suggested to be associated with increased MS disease susceptibility and activity. In CD4+ T cells, we have analyzed in vitro vitamin D responsiveness of genes that contain an MS-associated single-nucleotide polymorphism (SNP) and with one or more vitamin D response elements in their regulatory regions. We identify IL2RA and TAGAP as novel vitamin D target genes. The vitamin D response is observed in samples from both MS patients and controls, and is not dependent on the genotype of MS-associated SNPs in the respective genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.