ArticleNucleus (Austin, Tex.)2015
Chromatin structure and gene regulation: a dynamic view of enhancer function.
Article in Nucleus (Austin, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- DeepCORE: An interpretable multi-view deep neural network model to detect co-operative regulatory elements.Computational and structural biotechnology journal · 2024Article
- Unexpected nuclear hormone receptor and chromatin dynamics regulate estrous cycle dependent gene expression.Nucleic acids research · 2024Article
- Epigenetics in the formation of pathological aggregates in amyotrophic lateral sclerosis.Frontiers in molecular neuroscience · 2024Review
- Long-range gene regulation in hormone-dependent cancer.Nature reviews. Cancer · 2023Review
- Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- SMARCB1 Acts as a Quiescent Gatekeeper for Cell Cycle and Immune Response in Human Cells.International journal of molecular sciences · 2020Article
- Formation of correlated chromatin domains at nanoscale dynamic resolution during transcription.Nucleic acids research · 2018Article
- Genomic copy number variation analysis in multiple system atrophy.Molecular brain · 2017Article
- Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading.Nature communications · 2017Article
- Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics.Scientific reports · 2017Article
- More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?Transcription · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Localized chromatin organization is now recognized as an important determinant of cell identity and developmental pathways. Recent studies have demonstrated that these epigenetic states are unexpectedly dynamic and malleable. In this Extra view we will highlight the transient nature of stimulus-induced enhancer accessibility and its importance for transcription regulation. Using glucocorticoid receptor (GR) as a model system we will discuss spatiotemporal relationships between receptor/chromatin interactions, lifetimes of the DNase I hypersensitivity sites (DHSs), long-range interactions, and gene regulation. We propose that differential temporal activation and utilization of distal regulatory elements plays a role in directing divergent stimulus-induced transcriptional programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.