ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2015
Multiscale modeling and simulation of microtubule-motor-protein assemblies.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Nuclear deformation by microtubule molecular motors.PLoS computational biology · 2025Article
- Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly.Current biology : CB · 2024Article
- Article
- Active condensation of filaments under spatial confinement.Frontiers in physics · 2022Article
- Modeling spatiotemporally varying protein-protein interactions in CyLaKS, the Cytoskeleton Lattice-based Kinetic Simulator.The European physical journal. E, Soft matter · 2021Article
- Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors.The European physical journal. E, Soft matter · 2021Article
- Fundamentals of the logarithmic measure for revealing multimodal diffusion.Biophysical journal · 2021Article
- Filamentous active matter: Band formation, bending, buckling, and defects.Science advances · 2020Article
- Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling.eLife · 2020Article
- A Mechanistic View of Collective Filament Motion in Active Nematic Networks.Biophysical journal · 2020Article
- Extensile motor activity drives coherent motions in a model of interphase chromatin.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Microtubule Dynamics, Kinesin-1 Sliding, and Dynein Action Drive Growth of Cell Processes.Biophysical journal · 2018Article
- Molecular simulations of cellular processes.Biophysical reviews · 2017Review
- A theory that predicts behaviors of disordered cytoskeletal networks.Molecular systems biology · 2017Article
- Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast.Nature communications · 2017Article
- Contributions of Microtubule Dynamic Instability and Rotational Diffusion to Kinetochore Capture.Biophysical journal · 2017Article
- Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast.Science advances · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Microtubules and motor proteins self-organize into biologically important assemblies including the mitotic spindle and the centrosomal microtubule array. Outside of cells, microtubule-motor mixtures can form novel active liquid-crystalline materials driven out of equilibrium by adenosine triphosphate-consuming motor proteins. Microscopic motor activity causes polarity-dependent interactions between motor proteins and microtubules, but how these interactions yield larger-scale dynamical behavior such as complex flows and defect dynamics is not well understood. We develop a multiscale theory for microtubule-motor systems in which Brownian dynamics simulations of polar microtubules driven by motors are used to study microscopic organization and stresses created by motor-mediated microtubule interactions. We identify polarity-sorting and crosslink tether relaxation as two polar-specific sources of active destabilizing stress. We then develop a continuum Doi-Onsager model that captures polarity sorting and the hydrodynamic flows generated by these polar-specific active stresses. In simulations of active nematic flows on immersed surfaces, the active stresses drive turbulent flow dynamics and continuous generation and annihilation of disclination defects. The dynamics follow from two instabilities, and accounting for the immersed nature of the experiment yields unambiguous characteristic length and time scales. When turning off the hydrodynamics in the Doi-Onsager model, we capture formation of polar lanes as observed in the Brownian dynamics simulation.
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