Evidence map›Paper›PMID 26764597›Full record

ArticleCell host & microbe2016

Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.

Kristof Moonens, Pär Gideonsson, Suresh Subedi, Jeanna Bugaytsova, Ema Romaõ, Melissa Mendez, Jenny Nordén, Mahsa Fallah, Lena Rakhimova, Anna Shevtsova and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Microbiology and molecular biology reviews : MMBR · 2026
    Review
  4. Review
  5. Review
  6. Therapeutic suppression ofFrontiers in microbiology · 2026
    Article
  7. Update on the pathogenesis and clinical management ofWorld journal of gastrointestinal pathophysiology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Pivotal role ofFrontiers in medicine · 2024
    Review
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Kristof MoonensStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Pär GideonssonDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Suresh SubediStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Jeanna BugaytsovaDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Ema RomaõCellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Melissa MendezDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Jenny NordénDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Mahsa FallahDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Lena RakhimovaDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Anna ShevtsovaDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Martina LahmannSchool of Chemistry, Bangor University, Deiniol Road Bangor, Gwynedd LL57 2UW, UK.
Gaetano CastaldoStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Kristoffer BrännströmDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Fanny CoppensStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Alvin W LoStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Tor NyDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Jay V SolnickCenter for Comparative Medicine and California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Medicine and Department of Microbiology and Immunology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Guy VandenbusscheStructure and Function of Biological Membranes, Université Libre de Bruxelles, Triomflaan, 1050 Brussels, Belgium.
Stefan OscarsonCentre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
Lennart HammarströmDivision of Clinical Immunology, Karolinska Institute at Karolinska University Hospital, 141 86 Huddinge, Sweden.
Anna ArnqvistDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
Douglas E BergDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Serge MuyldermansCellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Thomas BorénDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden. Electronic address: thomas.boren@umu.se.
Han RemautStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: han.remaut@vib-vub.be.

Funding

Modulation of Outer Membrane Protein Expressin in Helicobacter pyloriR01AI070803 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SOLNICK, JAY V. · 2008 to 2012
$2.4M
Role of H. pylori Outer Membrane Proteins in Colonization and Host ResponseR01AI081037 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SOLNICK, JAY V. · 2009 to 2013
$1.1M
NIAID NIH HHS R01 AI070803NIAID NIH HHS R01 AI081037
6 · The paper itself

Abstract

The Helicobacter pylori adhesin BabA binds mucosal ABO/Le(b) blood group (bg) carbohydrates. BabA facilitates bacterial attachment to gastric surfaces, increasing strain virulence and forming a recognized risk factor for peptic ulcers and gastric cancer. High sequence variation causes BabA functional diversity, but the underlying structural-molecular determinants are unknown. We generated X-ray structures of representative BabA isoforms that reveal a polymorphic, three-pronged Le(b) binding site. Two diversity loops, DL1 and DL2, provide adaptive control to binding affinity, notably ABO versus O bg preference. H. pylori strains can switch bg preference with single DL1 amino acid substitutions, and can coexpress functionally divergent BabA isoforms. The anchor point for receptor binding is the embrace of an ABO fucose residue by a disulfide-clasped loop, which is inactivated by reduction. Treatment with the redox-active pharmaceutic N-acetylcysteine lowers gastric mucosal neutrophil infiltration in H. pylori-infected Le(b)-expressing mice, providing perspectives on possible H. pylori eradication therapies.

Indexed as

ABO Blood-Group SystemAdhesins, BacterialAnimalsBinding SitesHelicobacter InfectionsHelicobacter pyloriHumansMiceModels, MolecularPolysaccharidesProtein BindingABO Blood-Group SystemAdhesins, BacterialBabA protein, Helicobacter pyloriPolysaccharides

Identifiers

PMID26764597
PMCPMC4793151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.