ArticleProceedings of the National Academy of Sciences of the United States of America2016
Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 86 citations in OpenAlex.
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- Moesin integrates cortical and lamellar actin networks during Drosophila macrophage migration.Nature communications · 2025Article
- Traveling-wave chemotaxis of neutrophil-like HL-60 cells.Molecular biology of the cell · 2025Article
- Plants sum and subtract stimuli over different timescales.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Local negative feedback of Rac activity at the leading edge underlies a pilot pseudopod-like program for amoeboid cell guidance.PLoS biology · 2023Article
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- Understanding How Cells Probe the World: A Preliminary Step towards Modeling Cell Behavior?International journal of molecular sciences · 2023Article
- Art-science collaborations: Generators of new ideas and serendipitous events.Quantitative plant biology · 2023Article
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- Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking.eLife · 2022Article
- Is There a Need for a More Precise Description of Biomolecule Interactions to Understand Cell Function?Current issues in molecular biology · 2022Review
- Macropinocytosis and Cell Migration: Don't Drink and Drive….Sub-cellular biochemistry · 2022Article
- Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity.Nature communications · 2021Article
- Directional Persistence of Cell Migration in Schizophrenia Patient-Derived Olfactory Cells.International journal of molecular sciences · 2021Article
- Characterization of immune cell migration using microfabrication.Biophysical reviews · 2021Review
- Morphodynamic signatures of MDA-MB-231 single cells and cell doublets undergoing invasion in confined microenvironments.Scientific reports · 2021Article
- Analysis of barotactic and chemotactic guidance cues on directional decision-making ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells.Nature communications · 2020Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Chemotaxis, the directional migration of cells in a chemical gradient, is robust to fluctuations associated with low chemical concentrations and dynamically changing gradients as well as high saturating chemical concentrations. Although a number of reports have identified cellular behavior consistent with a directional memory that could account for behavior in these complex environments, the quantitative and molecular details of such a memory process remain unknown. Using microfluidics to confine cellular motion to a 1D channel and control chemoattractant exposure, we observed directional memory in chemotactic neutrophil-like cells. We modeled this directional memory as a long-lived intracellular asymmetry that decays slower than observed membrane phospholipid signaling. Measurements of intracellular dynamics revealed that moesin at the cell rear is a long-lived element that when inhibited, results in a reduction of memory. Inhibition of ROCK (Rho-associated protein kinase), downstream of RhoA (Ras homolog gene family, member A), stabilized moesin and directional memory while depolymerization of microtubules (MTs) disoriented moesin deposition and also reduced directional memory. Our study reveals that long-lived polarized cytoskeletal structures, specifically moesin, actomyosin, and MTs, provide a directional memory in neutrophil-like cells even as they respond on short time scales to external chemical cues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.