ArticleThe Journal of nutrition2016
Adiposity and Chronic Inflammation in Young Women Predict Inflammation during Normal Pregnancy in the Philippines.
Article in The Journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Association between Pre-Pregnancy BMI and Inflammatory Profile Trajectories during Pregnancy and Postpartum in Brazilian Women with Periodontitis: The IMPROVE Trial.International journal of environmental research and public health · 2022Trial
- Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study.The Journal of pediatrics · 2018 · on this mapTrial
- Lower Socioeconomic Status Predicts Increased Proinflammatory Signaling in Late Pregnancy: Evidence From a Filipino Cohort.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Markers of inflammation in obese pregnant women: Adenosine deaminase and high sensitive C - reactive protein.European journal of obstetrics & gynecology and reproductive biology: X · 2022Article
- Non-linear and non-additive associations between the pregnancy metabolome and birthweight.Environment international · 2021Article
- The Impact of Early-Life Exposures on Women's Reproductive Health in Adulthood.Current epidemiology reports · 2021Review
- Dietary β-Carotene on Postpartum Uterine Recovery in Mice: Crosstalk Between Gut Microbiota and Inflammation.Frontiers in immunology · 2021Article
- Association of maternal sleep before and during pregnancy with preterm birth and early infant sleep and temperament.Scientific reports · 2020Article
- Profiles of gene expression in maternal blood predict offspring birth weight in normal pregnancy.Journal of developmental origins of health and disease · 2019Article
- The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium.Paediatric and perinatal epidemiology · 2019Article
- Regulation of inflammation during gestation and birth outcomes: Inflammatory cytokine balance predicts birth weight and length.American journal of human biology : the official journal of the Human Biology Council · 2019Article
- Longitudinal associations between attachment quality in infancy, C-reactive protein in early childhood, and BMI in middle childhood: preliminary evidence from a CPS-referred sample.Attachment & human development · 2019Article
- Pre-pregnancy cardiovascular risk factors and racial disparities in birth outcomes: the Bogalusa Heart Study.BMC pregnancy and childbirth · 2018Article
- Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory?PloS one · 2017Article
- Early developmental exposures shape trade-offs between acquired and innate immunity in humans.Evolution, medicine, and public health · 2016Article
- Maternal plasma transforming growth factor-β1 (TGF-β1) and newborn size: the Araraquara Cohort Study.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundRates of overweight and obesity are on the rise globally, and excess adipose tissue may contribute to elevations in inflammation during pregnancy, leading to pregnancy complications and adverse birth outcomes.
objectiveThe purpose of this study was to evaluate adiposity and inflammation in young women as predictors of inflammation in the third trimester of pregnancy in a community-based sample of healthy women.
methodsFemale participants (24-30 y) in a prospective observational cohort study (Cebu Longitudinal Health and Nutrition Survey) were contacted between 2009 and 2014 to identify new pregnancies. A total of 309 women provided data from 409 pregnancies. An in-home interview was scheduled for the third trimester to collect pregnancy information, anthropometric measurements, and a blood sample. Circulating C-reactive protein (CRP) was measured with a high-sensitivity immunoassay. Data collected from assessments in 2005 and 2009 were used to assess body mass index (BMI) and CRP in young adulthood, before pregnancy. Robust regression models were implemented to evaluate BMI and CRP in young adulthood as predictors of pregnancy CRP.
resultsPre-pregnancy BMI was a stronger predictor of third-trimester circulating CRP than BMI in the third trimester. No association was found between pregnancy weight gain and CRP. Pre-pregnancy CRP was a significant predictor of CRP in pregnancy, independent of BMI.
conclusionsLevels of overweight/obesity and inflammation in young adulthood, before pregnancy, are important predictors of inflammation in the third trimester of pregnancy. These results may have implications for addressing the growing concern about the contribution of obesity to adverse birth outcomes, and they suggest that factors that influence the regulation of inflammation, before pregnancy and independent of adiposity, may be important in shaping the inflammatory response to pregnancy.
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