ReviewCold Spring Harbor symposia on quantitative biology2015
Imaging Transcription: Past, Present, and Future.
Review in Cold Spring Harbor symposia on quantitative biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- NuclampFISH enables cell sorting based on nuclear RNA expression for chromatin analysis.BMC genomics · 2025Article
- Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals.Chemical reviews · 2024Review
- Optogenetic dissection of transcriptional repression in a multicellular organism.Nature communications · 2024Article
- Article
- Recent Advances in Single-Molecule Tracking and Imaging Techniques.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023Review
- Multiomics Analysis Reveals Novel Genetic Determinants for Lens Differentiation, Structure, and Transparency.Biomolecules · 2023Review
- Multiple parameters shape the 3D chromatin structure of single nuclei at the doc locus in Drosophila.Nature communications · 2022Article
- Radial pair correlation of molecular brightness fluctuations maps protein diffusion as a function of oligomeric state within live-cell nuclear architecture.Biophysical journal · 2022Article
- Bromodomains regulate dynamic targeting of the PBAF chromatin-remodeling complex to chromatin hubs.Biophysical journal · 2022Article
- Spatio-temporal mRNA tracking in the early zebrafish embryo.Nature communications · 2021Article
- Genome-wide off-rates reveal how DNA binding dynamics shape transcription factor function.Molecular systems biology · 2020Article
- From a young BSJ member: advanced technologies encouraged me to dive into biophysics field.Biophysical reviews · 2020Article
- 50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms.Nature structural & molecular biology · 2019Review
- Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation.Molecular cell · 2019Article
- Toward mapping the human body at a cellular resolution.Molecular biology of the cell · 2018Review
- Dynamic enhancer function in the chromatin context.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- Measuring dynamics of eukaryotic transcription initiation: Challenges, insights and opportunities.Transcription · 2018Article
- Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells.Nature reviews. Genetics · 2017Review
- Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes.PLoS pathogens · 2017Article
- Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Transcription, the first step of gene expression, is exquisitely regulated in higher eukaryotes to ensure correct development and homeostasis. Traditional biochemical, genetic, and genomic approaches have proved successful at identifying factors, regulatory sequences, and potential pathways that modulate transcription. However, they typically only provide snapshots or population averages of the highly dynamic, stochastic biochemical processes involved in transcriptional regulation. Single-molecule live-cell imaging has, therefore, emerged as a complementary approach capable of circumventing these limitations. By observing sequences of molecular events in real time as they occur in their native context, imaging has the power to derive cause-and-effect relationships and quantitative kinetics to build predictive models of transcription. Ongoing progress in fluorescence imaging technology has brought new microscopes and labeling technologies that now make it possible to visualize and quantify the transcription process with single-molecule resolution in living cells and animals. Here we provide an overview of the evolution and current state of transcription imaging technologies. We discuss some of the important concepts they uncovered and present possible future developments that might solve long-standing questions in transcriptional regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.