Trial reportArchives of physical medicine and rehabilitation2016
Exercise Induces Peripheral Muscle But Not Cardiac Adaptations After Stroke: A Randomized Controlled Pilot Trial.
Trial report in Archives of physical medicine and rehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Combined cardiorespiratory and resistance training for people with stroke.The Cochrane database of systematic reviews · 2025Pooled it
- Optimizing physical fitness in chronic stroke patients: the impact of exercise training modality and dosage on maximal and sub-maximal fitness - a systematic review and meta-analysis.Journal of rehabilitation medicine · 2025Pooled it
- Physical rehabilitation approaches for the recovery of function and mobility following stroke.The Cochrane database of systematic reviews · 2025Pooled it
- Current exercise-based rehabilitation impacts on poststroke exercise capacity, blood pressure, and lipid control: a meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of stretching exercises on human gait: a systematic review and meta-analysis.F1000Research · 2020Pooled it
- Feasibility of a home-based physiotherapy intervention to promote post-stroke mobility: A randomized controlled pilot study.PloS one · 2022Trial
- Reduced cardiac workload and enhanced oxygen extraction during maximal exercise in recreational endurance runners.Open heart · 2026Observational
- Taking the Next Step in Neurologic Rehabilitation: Contributions of Intensity and Variability of Stepping Tasks During Locomotor Training.Physical therapy · 2025Review
- Enhancing Heart Rate-Based Estimation of Energy Expenditure and Exercise Intensity in Patients Post Stroke.Bioengineering (Basel, Switzerland) · 2024Article
- Article
- Cardiorespiratory factors related to the increase in oxygen consumption during exercise in individuals with stroke.PloS one · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo explore the physiological factors affecting exercise-induced changes in peak oxygen consumption and function poststroke.
designSingle-center, single-blind, randomized controlled pilot trial.
settingCommunity stroke services.
participantsAdults (N=40; age>50y; independent with/without stick) with stroke (diagnosed >6 mo previously) were recruited from 117 eligible participants. Twenty participants were randomized to the intervention group and 20 to the control group. No dropouts or adverse events were reported.
interventionsIntervention group: 19-week (3 times/wk) progressive mixed (aerobic/strength/balance/flexibility) community group exercise program. Control group: Matched duration home stretching program.
main outcome measures(1) Pre- and postintervention: maximal cardiopulmonary exercise testing with noninvasive (bioreactance) cardiac output measurements; and (2) functional outcome measures: 6-minute walk test; timed Up and Go test, and Berg Balance Scale.
resultsExercise improved peak oxygen consumption (18±5 to 21±5 mL/(kg⋅min); P<.01) and peak arterial-venous oxygen difference (9.2±2.7 to 11.4±2.9 mL of O2/100 mL of blood; P<.01), but did not alter cardiac output (17.2±4 to 17.7±4.2 L/min; P=.44) or cardiac power output (4.8±1.3 to 5.0±1.35 W; P=.45). A significant relation existed between change in peak oxygen consumption and change in peak arterial-venous oxygen difference (r=.507; P<.05), but not with cardiac output. Change in peak oxygen consumption did not strongly correlate with change in function.
conclusionsExercise induced peripheral muscle, but not cardiac output, adaptations after stroke. Implications for stroke clinical care should be explored further in a broader cohort.
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