SynthesisJournal of human genetics2016
Genome-wide association study reveals sex-specific selection signals against autosomal nucleotide variants.
Synthesis in Journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Sex-Specific Gene Expression Differences in Varicose Veins.Biomedicines · 2025Article
- In search of the genetic variants of human sex ratio at birth: was Fisher wrong about sex ratio evolution?Proceedings. Biological sciences · 2024Article
- Comprehensive whole-genome analyses of the UK Biobank reveal significant sex differences in both genotype missingness and allele frequency on the X chromosome.Human molecular genetics · 2024Article
- Genetic analyses identify widespread sex-differential participation bias.Nature genetics · 2021Article
- The Coupon Collection Behavior in Human Reproduction.Current biology : CB · 2020Article
- The global male-bias in sex ratio at birth is sustained by the sex ratio genotypes of replacement offspring.Genetica · 2019Article
- Genomic study and Medical Subject Headings enrichment analysis of early pregnancy rate and antral follicle numbers in Nelore heifers.Journal of animal science · 2017Article
- Expression quantitative trait loci for PI3K/AKT pathway.Medicine · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
A genome-wide association study (GWAS) was conducted to examine genetic associations of common autosomal nucleotide variants with sex in a Korean population with 4183 males and 4659 females. Nine genetic association signals were identified in four intragenic and five intergenic regions (P<5 × 10(-8)). Further analysis with an independent data set confirmed two intragenic association signals in the genes encoding protein phosphatase 1, regulatory subunit 12B (PPP1R12B, intron 12, rs1819043) and dynein, axonemal, heavy chain 11 (DNAH11, intron 61, rs10255013), which are directly involved in the reproductive system. This study revealed autosomal genetic variants associated with sex ratio by GWAS for the first time. This implies that genetic variants in proximity to the association signals may influence sex-specific selection and contribute to sex ratio variation. Further studies are required to reveal the mechanisms underlying sex-specific selection.
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