ArticleJournal of neurophysiology2016
Temporal correlations among functionally specialized striatal neural ensembles in reward-conditioned mice.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Learning dynamically regulates stimulus discrimination of ventral striatal D1 receptor expressing neurons.Science advances · 2026Article
- Inherited input and local transformations shape the spatiotemporal organization of pathway specific striatal signals for motivated behavior.bioRxiv : the preprint server for biology · 2026Article
- Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachment.Nature communications · 2026Article
- Learning dynamically regulates stimulus discrimination of ventral striatal D1 receptor expressing neurons.bioRxiv : the preprint server for biology · 2025Article
- Article
- Striatal function scrutinized through the PAN-TAN-FSI triumvirate.Frontiers in cellular neuroscience · 2025Review
- The learning primacy hypothesis of dopamine: reconsidering dopamine's dual functions.Frontiers in cellular neuroscience · 2025Review
- Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling.Nature neuroscience · 2024Article
- Insights into the interaction between time and reward prediction on the activity of striatal tonically active neurons: A pilot study in rhesus monkeys.Physiological reports · 2024Article
- Article
- The roles of surround inhibition for the intrinsic function of the striatum, analyzed in silico.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Alcohol potentiates multiple GABAergic inputs to dorsal striatum fast-spiking interneurons.Neuropharmacology · 2023Article
- Striatal ensemble activity in an innate naturalistic behavior.bioRxiv : the preprint server for biology · 2023Article
- GRIN lens applications for studying neurobiology of substance use disorder.Addiction neuroscience · 2022Article
- Cortical control of striatal fast-spiking interneuron synchrony.The Journal of physiology · 2022Article
- Translational neuronal ensembles: Neuronal microcircuits in psychology, physiology, pharmacology and pathology.Frontiers in systems neuroscience · 2022Review
- Implantable aptamer-field-effect transistor neuroprobes for in vivo neurotransmitter monitoring.Science advances · 2021Article
- Early impairment of thalamocortical circuit activity and coherence in a mouse model of Huntington's disease.Neurobiology of disease · 2021Article
- Article
- Compulsive alcohol consumption is regulated by dorsal striatum fast-spiking interneurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
As the major input to the basal ganglia, the striatum is innervated by a wide range of other areas. Overlapping input from these regions is speculated to influence temporal correlations among striatal ensembles. However, the network dynamics among behaviorally related neural populations in the striatum has not been extensively studied. We used large-scale neural recordings to monitor activity from striatal ensembles in mice undergoing Pavlovian reward conditioning. A subpopulation of putative medium spiny projection neurons (MSNs) was found to discriminate between cues that predicted the delivery of a reward and cues that predicted no specific outcome. These cells were preferentially located in lateral subregions of the striatum. Discriminating MSNs were more spontaneously active and more correlated than their nondiscriminating counterparts. Furthermore, discriminating fast spiking interneurons (FSIs) represented a highly prevalent group in the recordings, which formed a strongly correlated network with discriminating MSNs. Spike time cross-correlation analysis showed the existence of synchronized activity among FSIs and feedforward inhibitory modulation of MSN spiking by FSIs. These findings suggest that populations of functionally specialized (cue-discriminating) striatal neurons have distinct network dynamics that sets them apart from nondiscriminating cells, potentially to facilitate accurate behavioral responding during associative reward learning.
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