ArticleProceedings. Biological sciences2016
Ambient temperature influences tolerance to plant secondary compounds in a mammalian herbivore.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Ambient temperature and toxic diets constrain snake venom resistance in a desert rodent.Biology letters · 2025Article
- Warmer ambient temperatures reduce protein intake by a mammalian folivore.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Toxin tolerance across landscapes: Ecological exposure not a prerequisite.Functional ecology · 2022Article
- Impacts of climate change on the livestock food supply chain; a review of the evidence.Global food security · 2021Review
- A Case for Eustress in Grazing Animals.Frontiers in veterinary science · 2019Review
- Moose at their bioclimatic edge alter their behavior based on weather, landscape, and predators.Current zoology · 2018Article
- What to eat in a warming world: do increased temperatures necessitate hazardous duty pay?Oecologia · 2018Article
- Recent advances in plant-herbivore interactions.F1000Research · 2017Review
- The Woodrat Gut Microbiota as an Experimental System for Understanding Microbial Metabolism of Dietary Toxins.Frontiers in microbiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing evidence suggests that plant secondary compounds (PSCs) ingested by mammals become more toxic at elevated ambient temperatures, a phenomenon known as temperature-dependent toxicity. We investigated temperature-dependent toxicity in the desert woodrat (Neotoma lepida), a herbivorous rodent that naturally encounters PSCs in creosote bush (Larrea tridentata), which is a major component of its diet. First, we determined the maximum dose of creosote resin ingested by woodrats at warm (28-29°C) or cool (21-22°C) temperatures. Second, we controlled the daily dose of creosote resin ingested at warm, cool and room (25°C) temperatures, and measured persistence in feeding trials. At the warm temperature, woodrats ingested significantly less creosote resin; their maximum dose was two-thirds that of animals at the cool temperature. Moreover, woodrats at warm and room temperatures could not persist on the same dose of creosote resin as woodrats at the cool temperature. Our findings demonstrate that warmer temperatures reduce PSC intake and tolerance in herbivorous rodents, highlighting the potentially adverse consequences of temperature-dependent toxicity. These results will advance the field of herbivore ecology and may hone predictions of mammalian responses to climate change.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.