Evidence map›Paper›PMID 26763701›Full record

ReviewProceedings. Biological sciences2016

The pertussis enigma: reconciling epidemiology, immunology and evolution.

Matthieu Domenech de Cellès, Felicia M G Magpantay, Aaron A King, Pejman Rohani

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 163 citations in OpenAlex.

  1. Antimicrobial resistance inEpidemiology and infection · 2026
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Matthieu Domenech de CellèsDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Felicia M G MagpantayDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Aaron A KingDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA Department of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.
Pejman RohaniFogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA Odum School of Ecology, University of Georgia, Athens, GA 30602, USA College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA rohani@uga.edu.
University of Michigan–Ann Arbor · USNational Institutes of Health · USUniversity of Georgia · US

Funding

Understanding Transmission with Integrated Genetic and Epidemiologic InferenceU54GM111274 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDFORD, TREVOR BC · 2014 to 2018
$12.5M
Integrating immunology, epidemiology, and evolution to understand and control perR01AI101155 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KING, AARON A., ROHANI, PEJMAN · 2012 to 2016
$1.7M
NIAID NIH HHS 1R01AI101155NIAID NIH HHS R01 AI101155NIGMS NIH HHS U54 GM111274NIGMS NIH HHS U54-GM111274
6 · The paper itself

Abstract

Pertussis, a highly contagious respiratory infection, remains a public health priority despite the availability of vaccines for 70 years. Still a leading cause of mortality in developing countries, pertussis has re-emerged in several developed countries with high vaccination coverage. Resurgence of pertussis in these countries has routinely been attributed to increased awareness of the disease, imperfect vaccinal protection or high infection rates in adults. In this review, we first present 1980-2012 incidence data from 63 countries and show that pertussis resurgence is not universal. We further argue that the large geographical variation in trends probably precludes a simple explanation, such as the transition from whole-cell to acellular pertussis vaccines. Reviewing available evidence, we then propose that prevailing views on pertussis epidemiology are inconsistent with both historical and contemporary data. Indeed, we summarize epidemiological evidence showing that natural infection and vaccination both appear to provide long-term protection against transmission and disease, so that previously infected or vaccinated adults contribute little to overall transmission at a population level. Finally, we identify several promising avenues that may lead to a consistent explanation of global pertussis epidemiology and to more effective control strategies.

Indexed as

AdultBordetella pertussisCommunicable Diseases, EmergingDisease ReservoirsHumansIncidenceInfantInfant, NewbornMass VaccinationWhooping Coughinfection-derived immunitypertussispertussis epidemiologypertussis resurgencepertussis vaccinesvaccine-derived immunity

Identifiers

PMID26763701
PMCPMC4721090
OpenAlexW2260237638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.