ArticleInternational journal of bipolar disorders2016
Circadian rhythmicity in emerging mood disorders: state or trait marker?
Article in International journal of bipolar disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- A systematic review and meta-analysis of sleep and circadian rhythms disturbances in individuals at high-risk of developing or with early onset of bipolar disorders.Neuroscience and biobehavioral reviews · 2022Pooled it
- Efficacy and safety of bright light therapy for manic and depressive symptoms in patients with bipolar disorder: A systematic review and meta-analysis.Psychiatry and clinical neurosciences · 2020Pooled it
- The Theory of Metabolic Jet Lag in Bipolar Disorder: A Pilot Feasibility Study Exploring the Association Between Eating Rhythm Disruption and Illness Burden Parameters.Bipolar disorders · 2026Article
- Patterns of rest-activity rhythms from adolescence to young adulthood: a scoping review.Frontiers in sleep · 2026Review
- Twenty-four-hour Skin Temperature Rhythms in Young People With Emerging Mood Disorders: Relationships With Illness Subtypes and Clinical Stage.Journal of biological rhythms · 2025Article
- Forecasting the course of bipolar disorder using rest-activity rhythms: Protocol for a multi-study modelling project.Wellcome open research · 2025Article
- Diurnal variation of cardiac autonomic activity in adolescent non-suicidal self-injury.European archives of psychiatry and clinical neuroscience · 2024Article
- Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities.Frontiers in psychiatry · 2022Review
- Late and Instable Sleep Phasing is Associated With Irregular Eating Patterns in Eating Disorders.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020Article
- Role of biological rhythm dysfunction in the development and management of bipolar disorders: a review.General psychiatry · 2020Review
- Brief Research Report: A Pilot Study of Cognitive Behavioral Regulation Therapy (CBT-REG) for Young People at High Risk of Early Transition to Bipolar Disorders.Frontiers in psychiatry · 2020Article
- Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster.Behavior genetics · 2019Article
- Desynchronization of diurnal rhythms in bipolar disorder and borderline personality disorder.Translational psychiatry · 2018Article
- Graph theory applied to the analysis of motor activity in patients with schizophrenia and depression.PloS one · 2018Article
- Variability of activity patterns across mood disorders and time of day.BMC psychiatry · 2017Article
- A pilot study to determine whether combinations of objectively measured activity parameters can be used to differentiate between mixed states, mania, and bipolar depression.International journal of bipolar disorders · 2017Article
- Time of Day Differences in Neural Reward Functioning in Healthy Young Men.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Dysregulation of objectively assessed 24-hour motor activity patterns as a potential marker for bipolar I disorder: results of a community-based family study.Translational psychiatry · 2017Article
- Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges.Frontiers in cellular neuroscience · 2017Review
- Biological rhythms are independently associated with quality of life in bipolar disorder.International journal of bipolar disorders · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCircadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young people and/or first episode cases of unipolar and bipolar disorders.
methodsActigraphy was undertaken for about 14 days in 63 post-pubertal individuals aged 13-25 years with a recent onset of a mood disorder meeting recognised diagnostic criteria. We examined associations between three easily interpretable markers of circadian rhythm activity (amplitude, acrophase and rhythmicity index) and demography and clinical characteristics. Then, circadian markers were compared between diagnostic groups, controlling for potential confounders.
resultsLonger duration of illness was correlated with reduced circadian rhythmicity and lower levels of activity over 24 h. A delay in the timing of maximum activity was associated with the level of manic but not depressive symptoms. The circadian rhythmicity index differentiated unipolar from bipolar cases, and in bipolar but not unipolar disorder, the rhythmicity was less robust in those with more severe manic or depressive symptoms.
conclusionsLess robust circadian rhythmicity, especially associated with increasing symptom severity, may represent a more specific or a trait marker of young people with mood disorders who are at higher risk of a bipolar course of illness.
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